RT Journal Article
T1 Influence of size and surface capping on photoluminescence and cytotoxicity of gold nanoparticles.
A1 Fernandez-Ponce, Cecilia
A1 Muñoz-Miranda, Juan P
A1 de Los Santos, Desire M
A1 Aguado, Enrique
A1 Garcia-Cozar, Francisco
A1 Litran, Rocio
K1 Agent
K1 Capping
K1 Cell viability
K1 Cytotoxicity
K1 GSH
K1 Gold nanoparticles
K1 Photoluminescence
K1 Proliferation
K1 Semiconfocal microscopy
AB Hydrophilic and homogeneous sub-10 nm blue light-emitting gold nanoparticles (NPs) functionalized with different capping agents have been prepared by simple chemical routes. Structure, average, size, and surface characteristics of these NPs have been widely studied, and the stability of colloidal NP solutions at different pH values has been evaluated. Au NPs show blue PL emission, particularly in the GSH capped NPs, in which the thiol-metal core transference transitions considerably enhance the fluorescent emission. The influence of capping agent and NP size on cytotoxicity and on the fluorescent emission are analyzed and discussed in order to obtain Au NPs with suitable features for biomedical applications. Cytotoxicity of different types of gold NPs has been determined using NPs at high concentrations in both tumor cell lines and primary cells. All NPs used show high biocompatibility with low cytotoxicity even at high concentration, while Au-GSH NPs decrease viability and proliferation of both a tumor cell line and primary lymphocytes.
SN 1388-0764
YR 2018
FD 2018-10-24
LK http://hdl.handle.net/10668/13288
UL http://hdl.handle.net/10668/13288
LA en
DS RISalud
RD Apr 7, 2025