Publication: Impact of DNA repair, folate and glutathione gene polymorphisms on risk of non small cell lung cancer.
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2017-11-21
Authors
Pérez-Ramírez, Cristina
Cañadas-Garre, Marisa
Alnatsha, Ahmed
Villar, Eduardo
Delgado, Juan Ramón
Calleja-Hernández, Miguel Ángel
Faus-Dáder, María José
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Abstract
Lung cancer, particularly non-small cell lung cancer (NSCLC) subtype, is the leading cause of cancer-related death related worldwide. Numerous gene polymorphisms in DNA repair, folate and glutathione pathways have been associated with susceptibility of NSCLC. We conducted this study to evaluate the effects of ERCC1, ERCC2, ERCC5, XRCC1, XRCC3, MTHFR, MTR, MTHFD1, SLC19A1 and GSTP1 gene polymorphisms on risk of NSCLC. No association between these gene polymorphisms and susceptibility of NSCLC were found in our patients, suggesting that genetic variations in genes involved in DNA repair, folate and glutathione metabolism pathways may not influence the risk of NSCLC.
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MeSH Terms
Aged
Aged, 80 and over
Carcinoma, Non-Small-Cell Lung
DNA Damage
DNA Repair
Female
Genotype
Glutathione
Humans
Lung Neoplasms
Male
Middle Aged
Polymorphism, Single Nucleotide
Risk
Aged, 80 and over
Carcinoma, Non-Small-Cell Lung
DNA Damage
DNA Repair
Female
Genotype
Glutathione
Humans
Lung Neoplasms
Male
Middle Aged
Polymorphism, Single Nucleotide
Risk
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Keywords
DNA repair pathway, Folate metabolism pathway, Glutathione metabolism pathway, Non-small cell lung cancer, Polymorphisms, Risk