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Impact of DNA repair, folate and glutathione gene polymorphisms on risk of non small cell lung cancer.

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dc.contributor.authorPérez-Ramírez, Cristina
dc.contributor.authorCañadas-Garre, Marisa
dc.contributor.authorAlnatsha, Ahmed
dc.contributor.authorVillar, Eduardo
dc.contributor.authorDelgado, Juan Ramón
dc.contributor.authorCalleja-Hernández, Miguel Ángel
dc.contributor.authorFaus-Dáder, María José
dc.date.accessioned2023-01-25T10:02:06Z
dc.date.available2023-01-25T10:02:06Z
dc.date.issued2017-11-21
dc.description.abstractLung cancer, particularly non-small cell lung cancer (NSCLC) subtype, is the leading cause of cancer-related death related worldwide. Numerous gene polymorphisms in DNA repair, folate and glutathione pathways have been associated with susceptibility of NSCLC. We conducted this study to evaluate the effects of ERCC1, ERCC2, ERCC5, XRCC1, XRCC3, MTHFR, MTR, MTHFD1, SLC19A1 and GSTP1 gene polymorphisms on risk of NSCLC. No association between these gene polymorphisms and susceptibility of NSCLC were found in our patients, suggesting that genetic variations in genes involved in DNA repair, folate and glutathione metabolism pathways may not influence the risk of NSCLC.
dc.identifier.doi10.1016/j.prp.2017.11.015
dc.identifier.essn1618-0631
dc.identifier.pmid29254785
dc.identifier.unpaywallURLhttps://pureadmin.qub.ac.uk/ws/files/138222058/1_s2.0_S0344033817308956_main.pdf
dc.identifier.urihttp://hdl.handle.net/10668/11924
dc.issue.number1
dc.journal.titlePathology, research and practice
dc.journal.titleabbreviationPathol Res Pract
dc.language.isoen
dc.organizationHospital Universitario San Cecilio
dc.organizationHospital Universitario San Cecilio
dc.organizationHospital Universitario San Cecilio
dc.organizationHospital Universitario Virgen de las Nieves
dc.organizationHospital Universitario Virgen de las Nieves
dc.organizationHospital Universitario Virgen de las Nieves
dc.organizationHospital Universitario San Cecilio
dc.organizationHospital Universitario Virgen de las Nieves
dc.page.number44-52
dc.pubmedtypeJournal Article
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectDNA repair pathway
dc.subjectFolate metabolism pathway
dc.subjectGlutathione metabolism pathway
dc.subjectNon-small cell lung cancer
dc.subjectPolymorphisms
dc.subjectRisk
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshCarcinoma, Non-Small-Cell Lung
dc.subject.meshDNA Damage
dc.subject.meshDNA Repair
dc.subject.meshFemale
dc.subject.meshGenotype
dc.subject.meshGlutathione
dc.subject.meshHumans
dc.subject.meshLung Neoplasms
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPolymorphism, Single Nucleotide
dc.subject.meshRisk
dc.titleImpact of DNA repair, folate and glutathione gene polymorphisms on risk of non small cell lung cancer.
dc.typeresearch article
dc.type.hasVersionAM
dc.volume.number214
dspace.entity.typePublication

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