RT Journal Article
T1 Impact of DNA repair, folate and glutathione gene polymorphisms on risk of non small cell lung cancer.
A1 Pérez-Ramírez, Cristina
A1 Cañadas-Garre, Marisa
A1 Alnatsha, Ahmed
A1 Villar, Eduardo
A1 Delgado, Juan Ramón
A1 Calleja-Hernández, Miguel Ángel
A1 Faus-Dáder, María José
K1 DNA repair pathway
K1 Folate metabolism pathway
K1 Glutathione metabolism pathway
K1 Non-small cell lung cancer
K1 Polymorphisms
K1 Risk
AB Lung cancer, particularly non-small cell lung cancer (NSCLC) subtype, is the leading cause of cancer-related death related worldwide. Numerous gene polymorphisms in DNA repair, folate and glutathione pathways have been associated with susceptibility of NSCLC. We conducted this study to evaluate the effects of ERCC1, ERCC2, ERCC5, XRCC1, XRCC3, MTHFR, MTR, MTHFD1, SLC19A1 and GSTP1 gene polymorphisms on risk of NSCLC. No association between these gene polymorphisms and susceptibility of NSCLC were found in our patients, suggesting that genetic variations in genes involved in DNA repair, folate and glutathione metabolism pathways may not influence the risk of NSCLC.
YR 2017
FD 2017-11-21
LK http://hdl.handle.net/10668/11924
UL http://hdl.handle.net/10668/11924
LA en
DS RISalud
RD Apr 19, 2025