Publication: The immune boundaries for stem cell based therapies: problems and prospective solutions.
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Identifiers
Date
2009-08
Authors
Hmadcha, Abdelkrim
Domínguez-Bendala, Juan
Wakeman, Jane
Mohamed, Arredouani
Soria, Bernat
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
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Abstract
Stem cells have fascinated the scientific and clinical communities for over a century. Despite the controversy that surrounds this field, it is clear that stem cells have the potential to revolutionize medicine. However, a number of significant hurdles still stand in the way of the realization of this potential. Chiefly among these are safety concerns, differentiation efficiency and overcoming immune rejection. Here we review current progress made in this field to optimize the safe use of stem cells with particular emphasis on prospective interventions to deal with challenges generated by immune rejection.
Description
Journal Article; Research Support, Non-U.S. Gov't; Review;
MeSH Terms
Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immune System Processes::Transplantation Immunology::Host vs Graft Reaction::Graft Rejection
Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immune System Processes::Transplantation Immunology::Histocompatibility
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System
Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immune System Processes::Immunomodulation::Immune Tolerance
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Cell Transplantation::Stem Cell Transplantation
Medical Subject Headings::Anatomy::Cells::Stem Cells
Medical Subject Headings::Organisms::Eukaryota::Animals
Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immune System Processes::Transplantation Immunology::Histocompatibility
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System
Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immune System Processes::Immunomodulation::Immune Tolerance
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Cell Transplantation::Stem Cell Transplantation
Medical Subject Headings::Anatomy::Cells::Stem Cells
Medical Subject Headings::Organisms::Eukaryota::Animals
DeCS Terms
CIE Terms
Keywords
Stem cells, Histocompatibility, Immune rejection, Cell therapies, Células Madre, Histocompatibilidad, Tratamiento Basado en Trasplante de Células y Tejidos
Citation
Hmadcha A, Domínguez-Bendala J, Wakeman J, Mohamed, Soria B. The immune boundaries for stem cell based therapies: problems and prospective solutions. J. Cell. Mol. Med.. 2009; 13(8A):1464-75