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The immune boundaries for stem cell based therapies: problems and prospective solutions.

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dc.contributor.authorHmadcha, Abdelkrim
dc.contributor.authorDomínguez-Bendala, Juan
dc.contributor.authorWakeman, Jane
dc.contributor.authorMohamed, Arredouani
dc.contributor.authorSoria, Bernat
dc.contributor.authoraffiliation[Hmadcha,A; Soria,B] Department of Cell Therapy and Regenerative Medicine, Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), Sevilla, Spain. [Domínguez-Bendala,J] Pancreatic Development & Stem Cell Laboratory, Diabetes Research Institute, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA. [Wakeman,J] North West Cancer Research Fund Institute, School of Biological Sciences, University of Wales Bangor, Memorial Building, Gwynedd, UK. [Mohamed,A] Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USAes
dc.contributor.funderThis work was supported by the Consejería de Salud (Junta de Andalucía) and Fundación Progreso y Salud, the Spanish Ministry of Health, Red TerCel, North West Cancer Research Fund and Diabetes Research Institute Foundation
dc.date.accessioned2016-07-06T12:03:39Z
dc.date.available2016-07-06T12:03:39Z
dc.date.issued2009-08
dc.descriptionJournal Article; Research Support, Non-U.S. Gov't; Review;es
dc.description.abstractStem cells have fascinated the scientific and clinical communities for over a century. Despite the controversy that surrounds this field, it is clear that stem cells have the potential to revolutionize medicine. However, a number of significant hurdles still stand in the way of the realization of this potential. Chiefly among these are safety concerns, differentiation efficiency and overcoming immune rejection. Here we review current progress made in this field to optimize the safe use of stem cells with particular emphasis on prospective interventions to deal with challenges generated by immune rejection.es
dc.description.versionYeses
dc.identifier.citationHmadcha A, Domínguez-Bendala J, Wakeman J, Mohamed, Soria B. The immune boundaries for stem cell based therapies: problems and prospective solutions. J. Cell. Mol. Med.. 2009; 13(8A):1464-75es
dc.identifier.doi10.1111/j.1582-4934.2009.00837.x
dc.identifier.essn1582-4934
dc.identifier.issn1582-1838
dc.identifier.pmcPMC3828859
dc.identifier.pmid19583810
dc.identifier.urihttp://hdl.handle.net/10668/2256
dc.journal.titleJournal of Cellular and Molecular Medicine
dc.language.isoen
dc.publisherWileyes
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2009.00837.x/abstractes
dc.rights.accessRightsopen access
dc.subjectStem cellses
dc.subjectHistocompatibilityes
dc.subjectImmune rejectiones
dc.subjectCell therapieses
dc.subjectCélulas Madrees
dc.subjectHistocompatibilidades
dc.subjectTratamiento Basado en Trasplante de Células y Tejidoses
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immune System Processes::Transplantation Immunology::Host vs Graft Reaction::Graft Rejectiones
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immune System Processes::Transplantation Immunology::Histocompatibilityes
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Anatomy::Hemic and Immune Systems::Immune Systemes
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immune System Processes::Immunomodulation::Immune Tolerancees
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Cell Transplantation::Stem Cell Transplantationes
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Stem Cellses
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animalses
dc.titleThe immune boundaries for stem cell based therapies: problems and prospective solutions.es
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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