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Nalidixic acid surrogate test for susceptibility to ciprofloxacin in Salmonella. Revisiting the question.

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2018

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Guzmán-Martín, José Luis
Navarro-Marí, José María
Expósito-Ruiz, Manuela
Gutiérrez-Fernández, José

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Abstract

We investigated the reliability of nalidixic acid (NA) susceptibility as a marker of ciprofloxacin susceptibility in Salmonella, analysing 302 stool isolates. NC53 of the MicroScan system was used for NA susceptibility tests and the E-test was used for ciprofloxacin susceptibility tests. Among the isolates, 178 (58.9 %) were serogroup B, 74 (24.5 %) were serogroup D, 27 (8.9 %) were serogroup C and 23 (7.6 %) were from other minor serogroups. Globally, susceptibility to NA correctly predicted the susceptibility of Salmonella to ciprofloxacin, with a sensitivity of 81.5 %, a specificity of 97.6 %, and positive and negative predictive values of 88 and 96 %, respectively. However, there were differences among the serogroups in terms of sensitivity (P

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Anti-Bacterial Agents
Ciprofloxacin
Drug Resistance, Bacterial
Feces
Humans
Microbial Sensitivity Tests
Nalidixic Acid
Salmonella
Salmonella Infections
Serogroup

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Salmonella, ciprofloxacin, enteritis, nalidixic acid, stools

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