Publication: Nalidixic acid surrogate test for susceptibility to ciprofloxacin in Salmonella. Revisiting the question.
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Date
2018
Authors
Guzmán-Martín, José Luis
Navarro-Marí, José María
Expósito-Ruiz, Manuela
Gutiérrez-Fernández, José
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Abstract
We investigated the reliability of nalidixic acid (NA) susceptibility as a marker of ciprofloxacin susceptibility in Salmonella, analysing 302 stool isolates. NC53 of the MicroScan system was used for NA susceptibility tests and the E-test was used for ciprofloxacin susceptibility tests. Among the isolates, 178 (58.9 %) were serogroup B, 74 (24.5 %) were serogroup D, 27 (8.9 %) were serogroup C and 23 (7.6 %) were from other minor serogroups. Globally, susceptibility to NA correctly predicted the susceptibility of Salmonella to ciprofloxacin, with a sensitivity of 81.5 %, a specificity of 97.6 %, and positive and negative predictive values of 88 and 96 %, respectively. However, there were differences among the serogroups in terms of sensitivity (P
Description
MeSH Terms
Anti-Bacterial Agents
Ciprofloxacin
Drug Resistance, Bacterial
Feces
Humans
Microbial Sensitivity Tests
Nalidixic Acid
Salmonella
Salmonella Infections
Serogroup
Ciprofloxacin
Drug Resistance, Bacterial
Feces
Humans
Microbial Sensitivity Tests
Nalidixic Acid
Salmonella
Salmonella Infections
Serogroup
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Keywords
Salmonella, ciprofloxacin, enteritis, nalidixic acid, stools