Publication: Mycobacterium tuberculosis Acquires Limited Genetic Diversity in Prolonged Infections, Reactivations and Transmissions Involving Multiple Hosts
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2018-01-19
Authors
Herranz, Marta
Pole, Ilva
Ozere, Iveta
Chiner-Oms, Alvaro
Martinez-Lirola, Miguel
Perez-Garcia, Felipe
Gijon, Paloma
Ruiz Serrano, Maria Jesus
Clotet Romero, Laura
Cuevas, Oscar
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Frontiers media sa
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Abstract
Background: Mycobacterium tuberculosis (MTB) has limited ability to acquire variability. Analysis of its microevolution might help us to evaluate the pathways followed to acquire greater infective success. Whole-genome sequencing (WGS) in the analysis of the transmission of MTB has elucidated the magnitude of variability in MTB. Analysis of transmission currently depends on the identification of clusters, according to the threshold of variability (
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tuberculosis, variability, whole genome sequencing, SNPs, microevolution, Clonal variants, Microevolution, Outbreaks, Strain, Africa