Publication: Sleeve Gastrectomy and Roux-En-Y Gastric Bypass. Two Sculptors of the Pancreatic Islet
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2021-09-17
Authors
Pérez-Arana, Gonzalo-Martín
Fernández-Vivero, José
Camacho-Ramírez, Alonso
Díaz Gómez, Alfredo
Bancalero de Los Reyes, José
Ribelles-García, Antonio
Almorza-Gomar, David
Carrasco-Molinillo, Carmen
Prada-Oliveira, José-Arturo
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Abstract
Several surgical procedures are performed for the treatment of obesity. A main outcome of these procedures is the improvement of type 2 diabetes mellitus. Trying to explain this, gastrointestinal hormone levels and their effect on organs involved in carbohydrate metabolism, such as liver, gut, muscle or fat, have been studied intensively after bariatric surgery. These effects on endocrine-cell populations in the pancreas have been less well studied. We gathered the existing data on these pancreatic-cell populations after the two most common types of bariatric surgery, the sleeve gastrectomy (SG) and the roux-en-Y gastric bypass (RYGB), with the aim to explain the pathophysiological mechanisms underlying these surgeries and to improve their outcome.
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Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Bariatric Surgery::Gastric Bypass
Medical Subject Headings::Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 2
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Digestive System Surgical Procedures::Gastrectomy
Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Gastrointestinal Hormones
Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Carbohydrate Metabolism
Medical Subject Headings::Anatomy::Digestive System::Pancreas
Medical Subject Headings::Anatomy::Digestive System::Liver
Medical Subject Headings::Anatomy::Musculoskeletal System::Muscles
Medical Subject Headings::Anatomy::Cells
Medical Subject Headings::Anatomy::Endocrine System::Endocrine Glands::Islets of Langerhans
Medical Subject Headings::Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 2
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Digestive System Surgical Procedures::Gastrectomy
Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Gastrointestinal Hormones
Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Carbohydrate Metabolism
Medical Subject Headings::Anatomy::Digestive System::Pancreas
Medical Subject Headings::Anatomy::Digestive System::Liver
Medical Subject Headings::Anatomy::Musculoskeletal System::Muscles
Medical Subject Headings::Anatomy::Cells
Medical Subject Headings::Anatomy::Endocrine System::Endocrine Glands::Islets of Langerhans
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Keywords
Sleeve gastrectomy, Roux-en-Y gastric bypass, Beta-cell, Alpha-cell, Epsilon-cell, Islet, Trans-differentiation, Carbohydrate metabolism, Pancreas, Gastrectomía, Derivación gástrica, Islotes pancreáticos, Metabolismo de los hidratos de carbono, Páncreas, Células, Diabetes mellitus
Citation
Pérez-Arana GM, Fernández-Vivero J, Camacho-Ramírez A, Díaz Gómez A, Bancalero de Los Reyes J, Ribelles-García A, et al. Sleeve Gastrectomy and Roux-En-Y Gastric Bypass. Two Sculptors of the Pancreatic Islet. J Clin Med. 2021 Sep 17;10(18):4217.