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"Triple-negative" non-secretory medullary thyroid cancer: uncommon pathological findings in a rare disease.

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Date

2022-04-20

Authors

Martinez-Montoro, Jose Ignacio
Gomez-Perez, Ana Maria
Gallego, Elena
Garcia-Aleman, Jorge
Sebastian-Ochoa, Arantzazu
Damas-Fuentes, Miguel
Mancha-Doblas, Isabel
Tinahones, Francisco J

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Termedia sp. z o.o.,Termedia Publishing House
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Abstract

Medullary thyroid cancer (MTC) is a neuroendocrine tumor that arises from the calcitonin (CT)-producing thyroid parafollicular C cells, accounting for 3–4% of all thyroid cancers [1, 2]. CT constitutes the most specific and sensitive serum biomarker of MTC and correlates with tumor size [3], whereas different markers markers, such as carcinoembryonic antigen (CEA) and chromogranin A (CgA), are specific but often co-secreted by the tumor [2, 3]. Compared with other thyroid malignancies, MTC exhibits distinctive histopathological features, and the most important immunohistochemical markers are CT and CEA; in fact, in the absence of CT expression, the diagnosis of MTC should be questioned [4]. Also, amyloid material is often present at the histological examination [4]. Calcitonin-negative medullary thyroid cancer (CNMTC), determined by normal serum levels of CT, is a very rare presentation of MTC and only a few cases have been described in the literature [5]. Moreover, CNMTC is often positive for CT immunostaining [6]. In the current case, we report a CNMTC with negative CT, CEA and amyloid substance at the histopathological examination

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MeSH Terms

Thyroid neoplasms
Carcinoma, medullary
Calcitonin
Carcinoembryonic antigen
Chromogranins
Amyloid
Immunohistochemistry
Biomarkers, tumor
Neuroendocrine tumors

DeCS Terms

Neoplasias tiroideas
Carcinoma medular
Calcitonina
Antígeno carcinoembrionario
Cromograninas
Amiloide
Inmunohistoquímica
Biomarcadores tumorales
Tumores neuroendocrinos

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Keywords

Medullary thyroid cancer, Medullary thyroid cancer, Neuroendocrine tumor, Tumor markers, Immunohistochemistry, Carcinoembryonic antigen, Chromogranin A

Citation

Martínez-Montoro JI, Gómez-Pérez AM, Gallego E, García-Alemán J, Sebastián-Ochoa A, Damas-Fuentes M, et al. "Triple-negative" non-secretory medullary thyroid cancer: uncommon pathological findings in a rare disease. Arch Med Sci. 2022 Apr 20;18(3):825-828.