Publication: "Triple-negative" non-secretory medullary thyroid cancer: uncommon pathological findings in a rare disease.
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Identifiers
Date
2022-04-20
Authors
Martinez-Montoro, Jose Ignacio
Gomez-Perez, Ana Maria
Gallego, Elena
Garcia-Aleman, Jorge
Sebastian-Ochoa, Arantzazu
Damas-Fuentes, Miguel
Mancha-Doblas, Isabel
Tinahones, Francisco J
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Termedia sp. z o.o.,Termedia Publishing House
Abstract
Medullary thyroid cancer (MTC) is a neuroendocrine tumor that arises from the calcitonin (CT)-producing thyroid parafollicular C cells, accounting for 3–4% of all thyroid cancers [1, 2]. CT constitutes the most specific and sensitive serum biomarker of MTC and correlates with tumor size [3], whereas different markers markers, such as carcinoembryonic antigen (CEA) and chromogranin A (CgA), are specific but often co-secreted by the tumor [2, 3]. Compared with other thyroid malignancies, MTC exhibits distinctive histopathological features, and the most important immunohistochemical markers are CT and CEA; in fact, in the absence of CT expression, the diagnosis of MTC should be questioned [4]. Also, amyloid material is often present at the histological examination [4]. Calcitonin-negative medullary thyroid cancer (CNMTC), determined by normal serum levels of CT, is a very rare presentation of MTC and only a few cases have been described in the literature [5]. Moreover, CNMTC is often positive for CT immunostaining [6]. In the current case, we report a CNMTC with negative CT, CEA and amyloid substance at the histopathological examination
Description
MeSH Terms
Thyroid neoplasms
Carcinoma, medullary
Calcitonin
Carcinoembryonic antigen
Chromogranins
Amyloid
Immunohistochemistry
Biomarkers, tumor
Neuroendocrine tumors
Carcinoma, medullary
Calcitonin
Carcinoembryonic antigen
Chromogranins
Amyloid
Immunohistochemistry
Biomarkers, tumor
Neuroendocrine tumors
DeCS Terms
Neoplasias tiroideas
Carcinoma medular
Calcitonina
Antígeno carcinoembrionario
Cromograninas
Amiloide
Inmunohistoquímica
Biomarcadores tumorales
Tumores neuroendocrinos
Carcinoma medular
Calcitonina
Antígeno carcinoembrionario
Cromograninas
Amiloide
Inmunohistoquímica
Biomarcadores tumorales
Tumores neuroendocrinos
CIE Terms
Keywords
Medullary thyroid cancer, Medullary thyroid cancer, Neuroendocrine tumor, Tumor markers, Immunohistochemistry, Carcinoembryonic antigen, Chromogranin A
Citation
Martínez-Montoro JI, Gómez-Pérez AM, Gallego E, García-Alemán J, Sebastián-Ochoa A, Damas-Fuentes M, et al. "Triple-negative" non-secretory medullary thyroid cancer: uncommon pathological findings in a rare disease. Arch Med Sci. 2022 Apr 20;18(3):825-828.