RT Journal Article
T1 "Triple-negative" non-secretory medullary thyroid cancer: uncommon pathological findings in a rare disease.
A1 Martinez-Montoro, Jose Ignacio
A1 Gomez-Perez, Ana Maria
A1 Gallego, Elena
A1 Garcia-Aleman, Jorge
A1 Sebastian-Ochoa, Arantzazu
A1 Damas-Fuentes, Miguel
A1 Mancha-Doblas, Isabel
A1 Tinahones, Francisco J
K1 Medullary thyroid cancer
K1 Medullary thyroid cancer
K1 Neuroendocrine tumor
K1 Tumor markers
K1 Immunohistochemistry
K1 Carcinoembryonic antigen
K1 Chromogranin A
AB Medullary thyroid cancer (MTC) is a neuroendocrine tumor that arises from the calcitonin (CT)-producing thyroid parafollicular C cells, accounting for 3–4% of all thyroid cancers [1, 2]. CT constitutes the most specific and sensitive serum biomarker of MTC and correlates with tumor size [3], whereas different markers markers, such as carcinoembryonic antigen (CEA) and chromogranin A (CgA), are specific but often co-secreted by the tumor [2, 3]. Compared with other thyroid malignancies, MTC exhibits distinctive histopathological features, and the most important immunohistochemical markers are CT and CEA; in fact, in the absence of CT expression, the diagnosis of MTC should be questioned [4]. Also, amyloid material is often present at the histological examination [4]. Calcitonin-negative medullary thyroid cancer (CNMTC), determined by normal serum levels of CT, is a very rare presentation of MTC and only a few cases have been described in the literature [5]. Moreover, CNMTC is often positive for CT immunostaining [6]. In the current case, we report a CNMTC with negative CT, CEA and amyloid substance at the histopathological examination
PB Termedia sp. z o.o.,Termedia Publishing House
SN 1734-1922
YR 2022
FD 2022-04-20
LK http://hdl.handle.net/10668/21653
UL http://hdl.handle.net/10668/21653
LA en
NO Martínez-Montoro JI, Gómez-Pérez AM, Gallego E, García-Alemán J, Sebastián-Ochoa A, Damas-Fuentes M, et al. "Triple-negative" non-secretory medullary thyroid cancer: uncommon pathological findings in a rare disease. Arch Med Sci. 2022 Apr 20;18(3):825-828.
DS RISalud
RD Sep 3, 2025