%0 Journal Article
%A Martinez-Montoro, Jose Ignacio
%A Gomez-Perez, Ana Maria
%A Gallego, Elena
%A Garcia-Aleman, Jorge
%A Sebastian-Ochoa, Arantzazu
%A Damas-Fuentes, Miguel
%A Mancha-Doblas, Isabel
%A Tinahones, Francisco J
%T "Triple-negative" non-secretory medullary thyroid cancer: uncommon pathological findings in a rare disease.
%D 2022
%@ 1734-1922
%U http://hdl.handle.net/10668/21653
%X Medullary thyroid cancer (MTC) is a neuroendocrine tumor that arises from the calcitonin (CT)-producing thyroid parafollicular C cells, accounting for 3–4% of all thyroid cancers [1, 2]. CT constitutes the most specific and sensitive serum biomarker of MTC and correlates with tumor size [3], whereas different markers markers, such as carcinoembryonic antigen (CEA) and chromogranin A (CgA), are specific but often co-secreted by the tumor [2, 3]. Compared with other thyroid malignancies, MTC exhibits distinctive histopathological features, and the most important immunohistochemical markers are CT and CEA; in fact, in the absence of CT expression, the diagnosis of MTC should be questioned [4]. Also, amyloid material is often present at the histological examination [4]. Calcitonin-negative medullary thyroid cancer (CNMTC), determined by normal serum levels of CT, is a very rare presentation of MTC and only a few cases have been described in the literature [5]. Moreover, CNMTC is often positive for CT immunostaining [6]. In the current case, we report a CNMTC with negative CT, CEA and amyloid substance at the histopathological examination
%K Medullary thyroid cancer
%K Medullary thyroid cancer
%K Neuroendocrine tumor
%K Tumor markers
%K Immunohistochemistry
%K Carcinoembryonic antigen
%K Chromogranin A
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