Publication:
Neutrophil Extracellular Traps in Periodontitis

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Date

2020-06-19

Authors

Magán-Fernández, Antonio
Rasheed Al-Bakri, Sarmad Muayad
O'Valle, Francisco
Benavides-Reyes, Cristina
Abadía-Molina, Francisco
Mesa, Francisco

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Abstract

Neutrophils are key cells of the immune system and have a decisive role in fighting foreign pathogens in infectious diseases. Neutrophil extracellular traps (NETs) consist of a mesh of DNA enclosing antimicrobial peptides and histones that are released into extracellular space following neutrophil response to a wide range of stimuli, such as pathogens, host-derived mediators and drugs. Neutrophils can remain functional after NET formation and are important for periodontal homeostasis. Periodontitis is an inflammatory multifactorial disease caused by a dysbiosis state between the gingival microbiome and the immune response of the host. The pathogenesis of periodontitis includes an immune-inflammatory component in which impaired NET formation and/or elimination can be involved, contributing to an exacerbated inflammatory reaction and to the destruction of gingival tissue. In this review, we summarize the current knowledge about the role of NETs in the pathogenesis of periodontitis.

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Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunity::Immunity, Innate
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation
Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Granulocytes::Neutrophils
Medical Subject Headings::Diseases::Stomatognathic Diseases::Mouth Diseases::Periodontal Diseases::Periodontitis
Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Free Radicals::Reactive Oxygen Species
Medical Subject Headings::Anatomy::Cells
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Nuclear Proteins::Histones
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Homeostasis
Medical Subject Headings::Organisms::Bacteria::Bacteroidetes::Bacteroidaceae::Porphyromonas::Porphyromonas gingivalis

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Keywords

Innate immunity, Periodontitis, Neutrophil functions, Neutrophil extracellular traps, Inmunidad innata, Neutrófilos, Trampas extracelulares

Citation

Magán-Fernández A, Rasheed Al-Bakri SM, O'Valle F, Benavides-Reyes C, Abadía-Molina F, Mesa F. Neutrophil Extracellular Traps in Periodontitis. Cells. 2020 Jun 19;9(6):1494