Neutrophil Extracellular Traps in Periodontitis

Magán-Fernández, Antonio; Rasheed Al-Bakri, Sarmad Muayad; O'Valle, Francisco; Benavides-Reyes, Cristina; Abadía-Molina, Francisco; Mesa, Francisco

Publication:
Neutrophil Extracellular Traps in Periodontitis

dc.contributor.author	Magán-Fernández, Antonio
dc.contributor.author	Rasheed Al-Bakri, Sarmad Muayad
dc.contributor.author	O'Valle, Francisco
dc.contributor.author	Benavides-Reyes, Cristina
dc.contributor.author	Abadía-Molina, Francisco
dc.contributor.author	Mesa, Francisco
dc.contributor.authoraffiliation	[Magán-Fernández,A; Rasheed Al-Bakri;SM; Mesa,F] Periodontology Department, School of Dentistry, University of Granada, 18071 Granada, Spain. [O'Valle,F] Pathology Department, School of Medicine (IBIMER, CIBM), University of Granada, Granada, Spain. [O'Valle,F] Biosanitary Research Institute (IBS-GRANADA), University of Granada, Granada, Spain. [Benavides-Reyes,C] Department of Operative Dentistry, School of Dentistry, University of Granada, Granada, Spain. [Abadía-Molina,F] Department of Cell Biology, University of Granada, Granada, Spain. [Abadía-Molina,F] INYTA, Institute of Nutrition and Food Technology “José Mataix”, University of Granada, Armilla, Granada, Spain.
dc.date.accessioned	2022-07-15T12:50:17Z
dc.date.available	2022-07-15T12:50:17Z
dc.date.issued	2020-06-19
dc.description.abstract	Neutrophils are key cells of the immune system and have a decisive role in fighting foreign pathogens in infectious diseases. Neutrophil extracellular traps (NETs) consist of a mesh of DNA enclosing antimicrobial peptides and histones that are released into extracellular space following neutrophil response to a wide range of stimuli, such as pathogens, host-derived mediators and drugs. Neutrophils can remain functional after NET formation and are important for periodontal homeostasis. Periodontitis is an inflammatory multifactorial disease caused by a dysbiosis state between the gingival microbiome and the immune response of the host. The pathogenesis of periodontitis includes an immune-inflammatory component in which impaired NET formation and/or elimination can be involved, contributing to an exacerbated inflammatory reaction and to the destruction of gingival tissue. In this review, we summarize the current knowledge about the role of NETs in the pathogenesis of periodontitis.	es_ES
dc.description.version	Yes	es_ES
dc.identifier.citation	Magán-Fernández A, Rasheed Al-Bakri SM, O'Valle F, Benavides-Reyes C, Abadía-Molina F, Mesa F. Neutrophil Extracellular Traps in Periodontitis. Cells. 2020 Jun 19;9(6):1494	es_ES
dc.identifier.doi	10.3390/cells9061494	es_ES
dc.identifier.essn	2073-4409
dc.identifier.pmc	PMC7349145
dc.identifier.pmid	32575367	es_ES
dc.identifier.uri	http://hdl.handle.net/10668/3791
dc.journal.title	Cells
dc.language.iso	en
dc.page.number	18 p.
dc.publisher	MDPI	es_ES
dc.relation.publisherversion	https://www.mdpi.com/2073-4409/9/6/1494/htm	es_ES
dc.rights	Atribución 4.0 Internacional	*
dc.rights.accessRights	Acceso abierto	es_ES
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	Innate immunity	es_ES
dc.subject	Periodontitis	es_ES
dc.subject	Neutrophil functions	es_ES
dc.subject	Neutrophil extracellular traps	es_ES
dc.subject	Inmunidad innata	es_ES
dc.subject	Neutrófilos	es_ES
dc.subject	Trampas extracelulares	es_ES
dc.subject.mesh	Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA	es_ES
dc.subject.mesh	Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans	es_ES
dc.subject.mesh	Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunity::Immunity, Innate	es_ES
dc.subject.mesh	Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation	es_ES
dc.subject.mesh	Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Granulocytes::Neutrophils	es_ES
dc.subject.mesh	Medical Subject Headings::Diseases::Stomatognathic Diseases::Mouth Diseases::Periodontal Diseases::Periodontitis	es_ES
dc.subject.mesh	Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Free Radicals::Reactive Oxygen Species	es_ES
dc.subject.mesh	Medical Subject Headings::Anatomy::Cells	es_ES
dc.subject.mesh	Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Nuclear Proteins::Histones	es_ES
dc.subject.mesh	Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Homeostasis	es_ES
dc.subject.mesh	Medical Subject Headings::Organisms::Bacteria::Bacteroidetes::Bacteroidaceae::Porphyromonas::Porphyromonas gingivalis	es_ES
dc.title	Neutrophil Extracellular Traps in Periodontitis	es_ES
dc.type	review article
dc.type.hasVersion	VoR
dspace.entity.type	Publication