RT Journal Article
T1 Neutrophil Extracellular Traps in Periodontitis
A1 Magán-Fernández, Antonio
A1 Rasheed Al-Bakri, Sarmad Muayad
A1 O'Valle, Francisco
A1 Benavides-Reyes, Cristina
A1 Abadía-Molina, Francisco
A1 Mesa, Francisco
K1 Innate immunity
K1 Periodontitis
K1 Neutrophil functions
K1 Neutrophil extracellular traps
K1 Inmunidad innata
K1 Neutrófilos
K1 Trampas extracelulares
AB Neutrophils are key cells of the immune system and have a decisive role in fighting foreign pathogens in infectious diseases. Neutrophil extracellular traps (NETs) consist of a mesh of DNA enclosing antimicrobial peptides and histones that are released into extracellular space following neutrophil response to a wide range of stimuli, such as pathogens, host-derived mediators and drugs. Neutrophils can remain functional after NET formation and are important for periodontal homeostasis. Periodontitis is an inflammatory multifactorial disease caused by a dysbiosis state between the gingival microbiome and the immune response of the host. The pathogenesis of periodontitis includes an immune-inflammatory component in which impaired NET formation and/or elimination can be involved, contributing to an exacerbated inflammatory reaction and to the destruction of gingival tissue. In this review, we summarize the current knowledge about the role of NETs in the pathogenesis of periodontitis.
PB MDPI
YR 2020
FD 2020-06-19
LK http://hdl.handle.net/10668/3791
UL http://hdl.handle.net/10668/3791
LA en
NO Magán-Fernández A, Rasheed Al-Bakri SM, O'Valle F, Benavides-Reyes C, Abadía-Molina F, Mesa F. Neutrophil Extracellular Traps in Periodontitis. Cells. 2020 Jun 19;9(6):1494
DS RISalud
RD Apr 19, 2025