Publication: Methylphenidate ameliorates the homeostatic balance between levels of kynurenines in ADHD children.
No Thumbnail Available
Identifiers
Date
2021-06-17
Authors
Molina-Carballo, Antonio
Cubero-Millán, Isabel
Fernández-López, Luisa
Checa-Ros, Ana
Machado-Casas, Irene
Jerez-Calero, Antonio
Blanca-Jover, Enrique
Cantarero-Malagón, Antonio-Manuel
Uberos, José
Muñoz-Hoyos, Antonio
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Metrics
Export
Abstract
The kynurenine pathway of tryptophan metabolism has been involved in ADHD We quantified basal levels and daily fluctuations of tryptophan and several kynurenine metabolites, as well as their changes after treatment with methylphenidate (MPH). A total of 179 children were recruited, grouped into ADHD (n = 130) and healthy controls (CG,n = 49). Blood samples were drawn at 20:00 and 09:00 h and only in the ADHD group after 4.63±2.3 months of treatment. Nocturnal urine was collected between both draws. Factorial analysis (Stata12.0) was performed with Groups, Time, Hour of Day and Depressive Symptoms (DS) as factors. MPH significantly increased plasma Kynurenic acid (2.4 ± 1.03/2.78±1.3 ng/mL; baseline/post-treatment, morning; z = 1.96,p
Description
MeSH Terms
Attention Deficit Disorder with Hyperactivity
Central Nervous System Stimulants
Child
Humans
Kynurenic Acid
Kynurenine
Methylphenidate
Tryptophan
Central Nervous System Stimulants
Child
Humans
Kynurenic Acid
Kynurenine
Methylphenidate
Tryptophan
DeCS Terms
CIE Terms
Keywords
ADHD, Children, Daily rhythms, Depressive symptoms, Kynurenines