RT Journal Article
T1 Methylphenidate ameliorates the homeostatic balance between levels of kynurenines in ADHD children.
A1 Molina-Carballo, Antonio
A1 Cubero-Millán, Isabel
A1 Fernández-López, Luisa
A1 Checa-Ros, Ana
A1 Machado-Casas, Irene
A1 Jerez-Calero, Antonio
A1 Blanca-Jover, Enrique
A1 Cantarero-Malagón, Antonio-Manuel
A1 Uberos, José
A1 Muñoz-Hoyos, Antonio
K1 ADHD
K1 Children
K1 Daily rhythms
K1 Depressive symptoms
K1 Kynurenines
AB The kynurenine pathway of tryptophan metabolism has been involved in ADHD We quantified basal levels and daily fluctuations of tryptophan and several kynurenine metabolites, as well as their changes after treatment with methylphenidate (MPH). A total of 179 children were recruited, grouped into ADHD (n = 130) and healthy controls (CG,n = 49). Blood samples were drawn at 20:00 and 09:00 h and only in the ADHD group after 4.63±2.3 months of treatment. Nocturnal urine was collected between both draws. Factorial analysis (Stata12.0) was performed with Groups, Time, Hour of Day and Depressive Symptoms (DS) as factors. MPH significantly increased plasma Kynurenic acid (2.4 ± 1.03/2.78±1.3 ng/mL; baseline/post-treatment, morning; z = 1.96,p
YR 2021
FD 2021-06-17
LK http://hdl.handle.net/10668/18046
UL http://hdl.handle.net/10668/18046
LA en
DS RISalud
RD Apr 12, 2025