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Methylphenidate ameliorates the homeostatic balance between levels of kynurenines in ADHD children.

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dc.contributor.authorMolina-Carballo, Antonio
dc.contributor.authorCubero-Millán, Isabel
dc.contributor.authorFernández-López, Luisa
dc.contributor.authorCheca-Ros, Ana
dc.contributor.authorMachado-Casas, Irene
dc.contributor.authorJerez-Calero, Antonio
dc.contributor.authorBlanca-Jover, Enrique
dc.contributor.authorCantarero-Malagón, Antonio-Manuel
dc.contributor.authorUberos, José
dc.contributor.authorMuñoz-Hoyos, Antonio
dc.date.accessioned2023-02-09T11:41:04Z
dc.date.available2023-02-09T11:41:04Z
dc.date.issued2021-06-17
dc.description.abstractThe kynurenine pathway of tryptophan metabolism has been involved in ADHD We quantified basal levels and daily fluctuations of tryptophan and several kynurenine metabolites, as well as their changes after treatment with methylphenidate (MPH). A total of 179 children were recruited, grouped into ADHD (n = 130) and healthy controls (CG,n = 49). Blood samples were drawn at 20:00 and 09:00 h and only in the ADHD group after 4.63±2.3 months of treatment. Nocturnal urine was collected between both draws. Factorial analysis (Stata12.0) was performed with Groups, Time, Hour of Day and Depressive Symptoms (DS) as factors. MPH significantly increased plasma Kynurenic acid (2.4 ± 1.03/2.78±1.3 ng/mL; baseline/post-treatment, morning; z = 1.96,p
dc.identifier.doi10.1016/j.psychres.2021.114060
dc.identifier.essn1872-7123
dc.identifier.pmid34175711
dc.identifier.unpaywallURLhttps://doi.org/10.1016/j.psychres.2021.114060
dc.identifier.urihttp://hdl.handle.net/10668/18046
dc.journal.titlePsychiatry research
dc.journal.titleabbreviationPsychiatry Res
dc.language.isoen
dc.organizationHospital Universitario San Cecilio
dc.organizationHospital Universitario San Cecilio
dc.page.number114060
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectADHD
dc.subjectChildren
dc.subjectDaily rhythms
dc.subjectDepressive symptoms
dc.subjectKynurenines
dc.subject.meshAttention Deficit Disorder with Hyperactivity
dc.subject.meshCentral Nervous System Stimulants
dc.subject.meshChild
dc.subject.meshHumans
dc.subject.meshKynurenic Acid
dc.subject.meshKynurenine
dc.subject.meshMethylphenidate
dc.subject.meshTryptophan
dc.titleMethylphenidate ameliorates the homeostatic balance between levels of kynurenines in ADHD children.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number303
dspace.entity.typePublication

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