Publication: Distribution of Non-Persistent Endocrine Disruptors in Two Different Regions of the Human Brain.
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Date
2017-09-13
Authors
van der Meer, Thomas P
Artacho-Cordón, Francisco
Swaab, Dick F
Struik, Dicky
Makris, Konstantinos C
Wolffenbuttel, Bruce H R
Frederiksen, Hanne
van Vliet-Ostaptchouk, Jana V
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Abstract
Non-persistent endocrine disrupting chemicals (npEDCs) can affect multiple organs and systems in the body. Whether npEDCs can accumulate in the human brain is largely unknown. The major aim of this pilot study was to examine the presence of environmental phenols and parabens in two distinct brain regions: the hypothalamus and white-matter tissue. In addition, a potential association between these npEDCs concentrations and obesity was investigated. Post-mortem brain material was obtained from 24 individuals, made up of 12 obese and 12 normal-weight subjects (defined as body mass index (BMI) > 30 and BMI 30 and BMI
Description
MeSH Terms
Adult
Brain
Chromatography, Liquid
Endocrine Disruptors
Environmental Exposure
Environmental Pollutants
Female
Humans
Male
Obesity
Pilot Projects
Tandem Mass Spectrometry
Brain
Chromatography, Liquid
Endocrine Disruptors
Environmental Exposure
Environmental Pollutants
Female
Humans
Male
Obesity
Pilot Projects
Tandem Mass Spectrometry
DeCS Terms
CIE Terms
Keywords
bisphenol-A, brain, hypothalamus, methylparaben, obesity, parabens, phenols