Publication: Effects of Amerindian Genetic Ancestry on Clinical Variables and Therapy in Patients with Rheumatoid Arthritis.
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2017-11-01
Authors
Sánchez, Elena
García de la Torre, Ignacio
Sacnún, Mónica
Goñi, Mario
Berbotto, Guillermo
Paira, Sergio
Musuruana, Jorge Luis
Graf, César
Alvarellos, Alejandro
Messina, Osvaldo D
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Abstract
To define whether Amerindian genetic ancestry correlates with clinical and therapeutic variables in admixed individuals with rheumatoid arthritis (RA) from Latin America. Patients with RA (n = 1347) and healthy controls (n = 1012) from Argentina, Mexico, Chile, and Peru were included. Samples were genotyped for the Immunochip v1 using the Illumina platform. Clinical data were obtained through interviews or the clinical history. Percentage of Amerindian ancestry was comparable between cases and controls. Morning stiffness (p Amerindian ancestry protects against most major clinical criteria of RA, but regarding the association of RF with increased European ancestry, age, sex, and smoking are modifiers. Ancestry also correlates with the therapeutic profiles.
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MeSH Terms
Adult
Age Factors
Aged
Alleles
Anti-Inflammatory Agents, Non-Steroidal
Antirheumatic Agents
Argentina
Arthritis, Rheumatoid
Chile
Female
Genotype
Humans
Indians, North American
Indians, South American
Isoxazoles
Leflunomide
Male
Methotrexate
Mexico
Middle Aged
Peru
Radiography
Rheumatoid Factor
Sex Factors
Sulfasalazine
Age Factors
Aged
Alleles
Anti-Inflammatory Agents, Non-Steroidal
Antirheumatic Agents
Argentina
Arthritis, Rheumatoid
Chile
Female
Genotype
Humans
Indians, North American
Indians, South American
Isoxazoles
Leflunomide
Male
Methotrexate
Mexico
Middle Aged
Peru
Radiography
Rheumatoid Factor
Sex Factors
Sulfasalazine
DeCS Terms
CIE Terms
Keywords
ADMIXTURE, AMERINDIAN, LATIN AMERICAN, RHEUMATOID ARTHRITIS, SMOKING