Publication:
Effects of Amerindian Genetic Ancestry on Clinical Variables and Therapy in Patients with Rheumatoid Arthritis.

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dc.contributor.authorSánchez, Elena
dc.contributor.authorGarcía de la Torre, Ignacio
dc.contributor.authorSacnún, Mónica
dc.contributor.authorGoñi, Mario
dc.contributor.authorBerbotto, Guillermo
dc.contributor.authorPaira, Sergio
dc.contributor.authorMusuruana, Jorge Luis
dc.contributor.authorGraf, César
dc.contributor.authorAlvarellos, Alejandro
dc.contributor.authorMessina, Osvaldo D
dc.contributor.authorBabini, Alejandra
dc.contributor.authorStrusberg, Ingrid
dc.contributor.authorMarcos, Juan Carlos
dc.contributor.authorScherbarth, Hugo
dc.contributor.authorSpindler, Alberto
dc.contributor.authorQuinteros, Ana
dc.contributor.authorToloza, Sergio
dc.contributor.authorMoreno, José Luis C
dc.contributor.authorCatoggio, Luis J
dc.contributor.authorTate, Guillermo
dc.contributor.authorEimon, Alicia
dc.contributor.authorCitera, Gustavo
dc.contributor.authorPellet, Antonio Catalán
dc.contributor.authorNasswetter, Gustavo
dc.contributor.authorCardiel, Mario H
dc.contributor.authorMiranda, Pedro
dc.contributor.authorBallesteros, Francisco
dc.contributor.authorEsquivel-Valerio, Jorge A
dc.contributor.authorMaradiaga-Ceceña, Marco A
dc.contributor.authorAcevedo-Vásquez, Eduardo M
dc.contributor.authorGarcía, Conrado García
dc.contributor.authorTusié-Luna, Teresa
dc.contributor.authorPons-Estel, Bernardo A
dc.contributor.authorAlarcón-Riquelme, Marta E
dc.contributor.authorGENAR Study
dc.date.accessioned2023-01-25T10:01:13Z
dc.date.available2023-01-25T10:01:13Z
dc.date.issued2017-11-01
dc.description.abstractTo define whether Amerindian genetic ancestry correlates with clinical and therapeutic variables in admixed individuals with rheumatoid arthritis (RA) from Latin America. Patients with RA (n = 1347) and healthy controls (n = 1012) from Argentina, Mexico, Chile, and Peru were included. Samples were genotyped for the Immunochip v1 using the Illumina platform. Clinical data were obtained through interviews or the clinical history. Percentage of Amerindian ancestry was comparable between cases and controls. Morning stiffness (p Amerindian ancestry protects against most major clinical criteria of RA, but regarding the association of RF with increased European ancestry, age, sex, and smoking are modifiers. Ancestry also correlates with the therapeutic profiles.
dc.identifier.doi10.3899/jrheum.160485
dc.identifier.issn0315-162X
dc.identifier.pmid29093158
dc.identifier.unpaywallURLhttps://www.jrheum.org/content/jrheum/44/12/1804.full.pdf
dc.identifier.urihttp://hdl.handle.net/10668/11760
dc.issue.number12
dc.journal.titleThe Journal of rheumatology
dc.journal.titleabbreviationJ Rheumatol
dc.language.isoen
dc.organizationCentro Pfizer-Universidad de Granada-Junta de Andalucía de Genómica e Investigación Oncológica-GENYO
dc.page.number1804-1812
dc.pubmedtypeJournal Article
dc.rights.accessRightsopen access
dc.subjectADMIXTURE
dc.subjectAMERINDIAN
dc.subjectLATIN AMERICAN
dc.subjectRHEUMATOID ARTHRITIS
dc.subjectSMOKING
dc.subject.meshAdult
dc.subject.meshAge Factors
dc.subject.meshAged
dc.subject.meshAlleles
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal
dc.subject.meshAntirheumatic Agents
dc.subject.meshArgentina
dc.subject.meshArthritis, Rheumatoid
dc.subject.meshChile
dc.subject.meshFemale
dc.subject.meshGenotype
dc.subject.meshHumans
dc.subject.meshIndians, North American
dc.subject.meshIndians, South American
dc.subject.meshIsoxazoles
dc.subject.meshLeflunomide
dc.subject.meshMale
dc.subject.meshMethotrexate
dc.subject.meshMexico
dc.subject.meshMiddle Aged
dc.subject.meshPeru
dc.subject.meshRadiography
dc.subject.meshRheumatoid Factor
dc.subject.meshSex Factors
dc.subject.meshSulfasalazine
dc.titleEffects of Amerindian Genetic Ancestry on Clinical Variables and Therapy in Patients with Rheumatoid Arthritis.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number44
dspace.entity.typePublication

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