RT Journal Article
T1 Effects of Amerindian Genetic Ancestry on Clinical Variables and Therapy in Patients with Rheumatoid Arthritis.
A1 Sánchez, Elena
A1 García de la Torre, Ignacio
A1 Sacnún, Mónica
A1 Goñi, Mario
A1 Berbotto, Guillermo
A1 Paira, Sergio
A1 Musuruana, Jorge Luis
A1 Graf, César
A1 Alvarellos, Alejandro
A1 Messina, Osvaldo D
A1 Babini, Alejandra
A1 Strusberg, Ingrid
A1 Marcos, Juan Carlos
A1 Scherbarth, Hugo
A1 Spindler, Alberto
A1 Quinteros, Ana
A1 Toloza, Sergio
A1 Moreno, José Luis C
A1 Catoggio, Luis J
A1 Tate, Guillermo
A1 Eimon, Alicia
A1 Citera, Gustavo
A1 Pellet, Antonio Catalán
A1 Nasswetter, Gustavo
A1 Cardiel, Mario H
A1 Miranda, Pedro
A1 Ballesteros, Francisco
A1 Esquivel-Valerio, Jorge A
A1 Maradiaga-Ceceña, Marco A
A1 Acevedo-Vásquez, Eduardo M
A1 García, Conrado García
A1 Tusié-Luna, Teresa
A1 Pons-Estel, Bernardo A
A1 Alarcón-Riquelme, Marta E
A1 GENAR Study, 
K1 ADMIXTURE
K1 AMERINDIAN
K1 LATIN AMERICAN
K1 RHEUMATOID ARTHRITIS
K1 SMOKING
AB To define whether Amerindian genetic ancestry correlates with clinical and therapeutic variables in admixed individuals with rheumatoid arthritis (RA) from Latin America. Patients with RA (n = 1347) and healthy controls (n = 1012) from Argentina, Mexico, Chile, and Peru were included. Samples were genotyped for the Immunochip v1 using the Illumina platform. Clinical data were obtained through interviews or the clinical history. Percentage of Amerindian ancestry was comparable between cases and controls. Morning stiffness (p  Amerindian ancestry protects against most major clinical criteria of RA, but regarding the association of RF with increased European ancestry, age, sex, and smoking are modifiers. Ancestry also correlates with the therapeutic profiles.
SN 0315-162X
YR 2017
FD 2017-11-01
LK http://hdl.handle.net/10668/11760
UL http://hdl.handle.net/10668/11760
LA en
DS RISalud
RD Jun 1, 2025