Genetics of Tinnitus: An Emerging Area for Molecular Diagnosis and Drug Development.

Research Projects
Organizational Units
Journal Issue
Subjective tinnitus is the perception of sound in the absence of external or bodily-generated sounds. Chronic tinnitus is a highly prevalent condition affecting over 70 million people in Europe. A wide variety of comorbidities, including hearing loss, psychiatric disorders, neurodegenerative disorders, and temporomandibular joint (TMJ) dysfunction, have been suggested to contribute to the onset or progression of tinnitus; however, the precise molecular mechanisms of tinnitus are not well understood and the contribution of genetic and epigenetic factors remains unknown. Human genetic studies could enable the identification of novel molecular therapeutic targets, possibly leading to the development of novel pharmaceutical therapeutics. In this article, we briefly discuss the available evidence for a role of genetics in tinnitus and consider potential hurdles in designing genetic studies for tinnitus. Since multiple diseases have tinnitus as a symptom and the supporting genetic evidence is sparse, we propose various strategies to investigate the genetic underpinnings of tinnitus, first by showing evidence of heritability using concordance studies in twins, and second by improving patient selection according to phenotype and/or etiology in order to control potential biases and optimize genetic data output. The increased knowledge resulting from this endeavor could ultimately improve the drug development process and lead to the preventive or curative treatment of tinnitus.
Journal Article; Review;
MeSH Terms
Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Bias (Epidemiology)
Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Factors::Comorbidity
Medical Subject Headings::Diseases::Otorhinolaryngologic Diseases::Ear Diseases::Hearing Disorders::Hearing Loss::Deafness
Medical Subject Headings::Geographicals::Geographic Locations::Europe
Medical Subject Headings::Disciplines and Occupations::Health Occupations::Medicine::Genetics, Medical
Medical Subject Headings::Diseases::Otorhinolaryngologic Diseases::Ear Diseases::Hearing Disorders::Hearing Loss
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Psychiatry and Psychology::Mental Disorders
Medical Subject Headings::Diseases::Nervous System Diseases::Neurodegenerative Diseases
Medical Subject Headings::Health Care::Health Services Administration::Patient Care Management::Patient Selection
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype
Medical Subject Headings::Diseases::Stomatognathic Diseases::Temporomandibular Joint Disorders::Temporomandibular Joint Dysfunction Syndrome
Medical Subject Headings::Anatomy::Stomatognathic System::Temporomandibular Joint
Medical Subject Headings::Diseases::Otorhinolaryngologic Diseases::Ear Diseases::Hearing Disorders::Tinnitus
DeCS Terms
CIE Terms
Epidemiology, Genetic, Hearing loss, Tinnitus, Meniere’s disease, Phenotyping, Subtype, Comorbilidad, Sordera, Europa (Continente), Genética médica, Pérdida auditiva, Humanos, Trastornos mentales, Enfermedades neurodegenerativas, Selección de paciente, Fenotipo, Síndrome de la disfunción de articulación temporomandibular, Articulación temporomandibular, Acúfeno
Lopez-Escamez JA, Bibas T, Cima RF, Van de Heyning P, Knipper M, Mazurek B, et al. Genetics of Tinnitus: An Emerging Area for Molecular Diagnosis and Drug Development. Front Neurosci. 2016; 10:377