Genetics of Tinnitus: An Emerging Area for Molecular Diagnosis and Drug Development.

dc.contributor.authorLopez-Escamez, Jose A
dc.contributor.authorBibas, Thanos
dc.contributor.authorCima, Rilana F F
dc.contributor.authorVan de Heyning, Paul
dc.contributor.authorKnipper, Marlies
dc.contributor.authorMazurek, Birgit
dc.contributor.authorSzczepek, Agnieszka J
dc.contributor.authorCederroth, Christopher R
dc.contributor.authoraffiliation[Lopez-Escamez,JA] Otology and Neurotology Group, Department of Genomic Medicine, Pfizer ,Universidad de Granada, Junta de Andalucía Centro de Genómica e Investigación Oncológica. Department of Otolaryngology, Instituto de Investigación Biosanitaria ibs.GRANADA, Complejo Hospital Universitario Granada, Granada, Spain. [Bibas,T] 1st Department of Otolaryngology, National and Kapodistrian University of Athens, Hippocrateion Hospital, Athens, Greece.Ear Institute, UCL, London, UK. [Cima,RFF] Department of Clinical Psychological Science, Maastricht University, Maastricht, Netherlands. [Van de Heyning,P] University Department ENT and Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium. [Knipper,M] Hearing Research Centre Tübingen, Molecular Physiology of Hearing, Tübingen, Germany. [Mazurek,B] Tinnitus Center, Charité-Universitätsmedizin Berlin, Berlin, Germany. [Szczepek,AJ] Department of ORL, Charité-Universitätsmedizin Berlin, Berlin, Germany. [Cederroth,CR] Experimental Audiology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm,
dc.contributor.funderThis work is supported by an independent research program funded under the Biomedicine and Molecular Biosciences European Cooperation in Science and Technology (COST) Action framework (TINNET BM1306).
dc.descriptionJournal Article; Review;es
dc.description.abstractSubjective tinnitus is the perception of sound in the absence of external or bodily-generated sounds. Chronic tinnitus is a highly prevalent condition affecting over 70 million people in Europe. A wide variety of comorbidities, including hearing loss, psychiatric disorders, neurodegenerative disorders, and temporomandibular joint (TMJ) dysfunction, have been suggested to contribute to the onset or progression of tinnitus; however, the precise molecular mechanisms of tinnitus are not well understood and the contribution of genetic and epigenetic factors remains unknown. Human genetic studies could enable the identification of novel molecular therapeutic targets, possibly leading to the development of novel pharmaceutical therapeutics. In this article, we briefly discuss the available evidence for a role of genetics in tinnitus and consider potential hurdles in designing genetic studies for tinnitus. Since multiple diseases have tinnitus as a symptom and the supporting genetic evidence is sparse, we propose various strategies to investigate the genetic underpinnings of tinnitus, first by showing evidence of heritability using concordance studies in twins, and second by improving patient selection according to phenotype and/or etiology in order to control potential biases and optimize genetic data output. The increased knowledge resulting from this endeavor could ultimately improve the drug development process and lead to the preventive or curative treatment of
dc.identifier.citationLopez-Escamez JA, Bibas T, Cima RF, Van de Heyning P, Knipper M, Mazurek B, et al. Genetics of Tinnitus: An Emerging Area for Molecular Diagnosis and Drug Development. Front Neurosci. 2016; 10:377es
dc.journal.titleFrontiers in Neuroscience
dc.publisherFrontiers Mediaes
dc.rights.accessRightsopen access
dc.subjectHearing losses
dc.subjectMeniere’s diseasees
dc.subjectEuropa (Continente)es
dc.subjectGenética médicaes
dc.subjectPérdida auditivaes
dc.subjectTrastornos mentaleses
dc.subjectEnfermedades neurodegenerativases
dc.subjectSelección de pacientees
dc.subjectSíndrome de la disfunción de articulación temporomandibulares
dc.subjectArticulación temporomandibulares
dc.subject.meshMedical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Bias (Epidemiology)es
dc.subject.meshMedical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Factors::Comorbidityes
dc.subject.meshMedical Subject Headings::Diseases::Otorhinolaryngologic Diseases::Ear Diseases::Hearing Disorders::Hearing Loss::Deafnesses
dc.subject.meshMedical Subject Headings::Geographicals::Geographic Locations::Europees
dc.subject.meshMedical Subject Headings::Disciplines and Occupations::Health Occupations::Medicine::Genetics, Medicales
dc.subject.meshMedical Subject Headings::Diseases::Otorhinolaryngologic Diseases::Ear Diseases::Hearing Disorders::Hearing Losses
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Psychiatry and Psychology::Mental Disorderses
dc.subject.meshMedical Subject Headings::Diseases::Nervous System Diseases::Neurodegenerative Diseaseses
dc.subject.meshMedical Subject Headings::Health Care::Health Services Administration::Patient Care Management::Patient Selectiones
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotypees
dc.subject.meshMedical Subject Headings::Diseases::Stomatognathic Diseases::Temporomandibular Joint Disorders::Temporomandibular Joint Dysfunction Syndromees
dc.subject.meshMedical Subject Headings::Anatomy::Stomatognathic System::Temporomandibular Jointes
dc.subject.meshMedical Subject Headings::Diseases::Otorhinolaryngologic Diseases::Ear Diseases::Hearing Disorders::Tinnituses
dc.titleGenetics of Tinnitus: An Emerging Area for Molecular Diagnosis and Drug
dc.typeresearch article
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