RT Journal Article
T1 Genetics of Tinnitus: An Emerging Area for Molecular Diagnosis and Drug Development.
A1 Lopez-Escamez, Jose A
A1 Bibas, Thanos
A1 Cima, Rilana F F
A1 Van de Heyning, Paul
A1 Knipper, Marlies
A1 Mazurek, Birgit
A1 Szczepek, Agnieszka J
A1 Cederroth, Christopher R
K1 Epidemiology
K1 Genetic
K1 Hearing loss
K1 Tinnitus
K1 Meniere’s disease
K1 Phenotyping
K1 Subtype
K1 Comorbilidad
K1 Sordera
K1 Europa (Continente)
K1 Genética médica
K1 Pérdida auditiva
K1 Humanos
K1 Trastornos mentales
K1 Enfermedades neurodegenerativas
K1 Selección de paciente
K1 Fenotipo
K1 Síndrome de la disfunción de articulación temporomandibular
K1 Articulación temporomandibular
K1 Acúfeno
AB Subjective tinnitus is the perception of sound in the absence of external or bodily-generated sounds. Chronic tinnitus is a highly prevalent condition affecting over 70 million people in Europe. A wide variety of comorbidities, including hearing loss, psychiatric disorders, neurodegenerative disorders, and temporomandibular joint (TMJ) dysfunction, have been suggested to contribute to the onset or progression of tinnitus; however, the precise molecular mechanisms of tinnitus are not well understood and the contribution of genetic and epigenetic factors remains unknown. Human genetic studies could enable the identification of novel molecular therapeutic targets, possibly leading to the development of novel pharmaceutical therapeutics. In this article, we briefly discuss the available evidence for a role of genetics in tinnitus and consider potential hurdles in designing genetic studies for tinnitus. Since multiple diseases have tinnitus as a symptom and the supporting genetic evidence is sparse, we propose various strategies to investigate the genetic underpinnings of tinnitus, first by showing evidence of heritability using concordance studies in twins, and second by improving patient selection according to phenotype and/or etiology in order to control potential biases and optimize genetic data output. The increased knowledge resulting from this endeavor could ultimately improve the drug development process and lead to the preventive or curative treatment of tinnitus.
PB Frontiers Media
SN 1662-453X
YR 2016
FD 2016-08-19
LK http://hdl.handle.net/10668/2464
UL http://hdl.handle.net/10668/2464
LA en
NO Lopez-Escamez JA, Bibas T, Cima RF, Van de Heyning P, Knipper M, Mazurek B, et al. Genetics of Tinnitus: An Emerging Area for Molecular Diagnosis and Drug Development. Front Neurosci. 2016; 10:377
NO Journal Article; Review;
DS RISalud
RD Apr 5, 2025