Publication:
Renal Function Impact in the Prognostic Value of Galectin-3 in Acute Heart Failure.

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Date

2022-04-07

Authors

Caravaca Perez, Pedro
Gonzalez-Juanatey, Jose R
Nuche, Jorge
Matute-Blanco, Lucia
Serrano, Isabel
Martinez Selles, Manuel
Vazquez Garcia, Rafael
Martinez Dolz, Luis
Gomez-Bueno, Manuel
Pascual Figal, Domingo

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Frontiers Research Foundation
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Abstract

Galectin-3 (Gal-3) is an inflammatory marker associated with the development and progression of heart failure (HF). A close relationship between Gal-3 levels and renal function has been observed, but data on their interaction in patients with acute HF (AHF) are scarce. We aim to assess the prognostic relationship between renal function and Gal-3 during an AHF episode. This is an observational, prospective, multicenter registry of patients hospitalized for AHF. Patients were divided into two groups according to estimated glomerular filtration rate (eGFR): preserved renal function (eGFR ≥ 60 mL/min/1.73 m2) and renal dysfunction (eGFR We included 1,201 patients in whom Gal-3 values were assessed at admission. The median value of Gal-3 in our population was 23.2 ng/mL (17.3-32.1). Gal-3 showed a negative correlation with eGFR (rho = -0.51; p Gal-3 is a marker of high mortality in patients with acute HF and renal dysfunction. Renal function influences the prognostic value of Gal-3 levels, which should be adjusted by eGFR for a correct interpretation.

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MeSH Terms

Galectin 3
Prognosis
Glomerular filtration rate
Prospective studies
Heart failure
Kidney
Kidney diseases
Registries

DeCS Terms

Enfermedades renales
Estudios prospectivos
Galectina 3
Insuficiencia cardíaca
Pronóstico
Riñón
Sistema de registros
Tasa de filtración glomerular

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Keywords

Acute heart failure (AHF), Cardiorenal syndrome (CRS), Galectin-3 (Gal-3), Prognosis, Renal function

Citation

Caravaca Perez P, González-Juanatey JR, Nuche J, Matute-Blanco L, Serrano I, Martínez Selles M, et al. Renal Function Impact in the Prognostic Value of Galectin-3 in Acute Heart Failure. Front Cardiovasc Med. 2022 Apr 7;9:861651