RT Journal Article
T1 Renal Function Impact in the Prognostic Value of Galectin-3 in Acute Heart Failure.
A1 Caravaca Perez, Pedro
A1 Gonzalez-Juanatey, Jose R
A1 Nuche, Jorge
A1 Matute-Blanco, Lucia
A1 Serrano, Isabel
A1 Martinez Selles, Manuel
A1 Vazquez Garcia, Rafael
A1 Martinez Dolz, Luis
A1 Gomez-Bueno, Manuel
A1 Pascual Figal, Domingo
A1 Crespo-Leiro, Maria G
A1 Garcia-Osuna, Alvaro
A1 Ordoñez-Llanos, Jordi
A1 Cinca Cuscullola, Juan
A1 Guerra, Jose M
A1 Delgado, Juan F
K1 Acute heart failure (AHF)
K1 Cardiorenal syndrome (CRS)
K1 Galectin-3 (Gal-3)
K1 Prognosis
K1 Renal function
AB Galectin-3 (Gal-3) is an inflammatory marker associated with the development and progression of heart failure (HF). A close relationship between Gal-3 levels and renal function has been observed, but data on their interaction in patients with acute HF (AHF) are scarce. We aim to assess the prognostic relationship between renal function and Gal-3 during an AHF episode. This is an observational, prospective, multicenter registry of patients hospitalized for AHF. Patients were divided into two groups according to estimated glomerular filtration rate (eGFR): preserved renal function (eGFR ≥ 60 mL/min/1.73 m2) and renal dysfunction (eGFR  We included 1,201 patients in whom Gal-3 values were assessed at admission. The median value of Gal-3 in our population was 23.2 ng/mL (17.3-32.1). Gal-3 showed a negative correlation with eGFR (rho = -0.51; p  Gal-3 is a marker of high mortality in patients with acute HF and renal dysfunction. Renal function influences the prognostic value of Gal-3 levels, which should be adjusted by eGFR for a correct interpretation.
PB Frontiers Research Foundation
SN 2297-055X
YR 2022
FD 2022-04-07
LK http://hdl.handle.net/10668/20548
UL http://hdl.handle.net/10668/20548
LA en
NO Caravaca Perez P, González-Juanatey JR, Nuche J, Matute-Blanco L, Serrano I, Martínez Selles M, et al.  Renal Function Impact in the Prognostic Value of Galectin-3 in Acute Heart Failure. Front Cardiovasc Med. 2022 Apr 7;9:861651
NO Bio-Merieux provided the reagents for Galectin-3 analysis free of charge. The company was not involved in the study design, data collection and statistical exploitation, or manuscript writing.
DS RISalud
RD Apr 4, 2025