Publication: A pleiotropic variant in DNAJB4 is associated with multiple myeloma risk.
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Date
2022-10-01
Authors
Dicanio, Marco
Giaccherini, Matteo
Clay-Gilmour, Alyssa
Macauda, Angelica
Sainz, Juan
Machiela, Mitchell J
Rybicka-Ramos, Malwina
Norman, Aaron D
Tyczyńska, Agata
Chanock, Stephen J
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Abstract
Pleiotropy, which consists of a single gene or allelic variant affecting multiple unrelated traits, is common across cancers, with evidence for genome-wide significant loci shared across cancer and noncancer traits. This feature is particularly relevant in multiple myeloma (MM) because several susceptibility loci that have been identified to date are pleiotropic. Therefore, the aim of this study was to identify novel pleiotropic variants involved in MM risk using 28 684 independent single nucleotide polymorphisms (SNPs) from GWAS Catalog that reached a significant association (P
Description
MeSH Terms
Humans
Multiple Myeloma
Oncogenes
Alleles
Phenotype
Polymorphism, Single Nucleotide
Genome-Wide Association Study
Genetic Predisposition to Disease
HSP40 Heat-Shock Proteins
DNA-Binding Proteins
RNA-Binding Proteins
Multiple Myeloma
Oncogenes
Alleles
Phenotype
Polymorphism, Single Nucleotide
Genome-Wide Association Study
Genetic Predisposition to Disease
HSP40 Heat-Shock Proteins
DNA-Binding Proteins
RNA-Binding Proteins
DeCS Terms
CIE Terms
Keywords
genetic susceptibility, multiple myeloma, pleiotropy, pleiotropy scan, polymorphisms