Publication:
A pleiotropic variant in DNAJB4 is associated with multiple myeloma risk.

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dc.contributor.authorDicanio, Marco
dc.contributor.authorGiaccherini, Matteo
dc.contributor.authorClay-Gilmour, Alyssa
dc.contributor.authorMacauda, Angelica
dc.contributor.authorSainz, Juan
dc.contributor.authorMachiela, Mitchell J
dc.contributor.authorRybicka-Ramos, Malwina
dc.contributor.authorNorman, Aaron D
dc.contributor.authorTyczyńska, Agata
dc.contributor.authorChanock, Stephen J
dc.contributor.authorBarington, Torben
dc.contributor.authorKumar, Shaji K
dc.contributor.authorBhatti, Parveen
dc.contributor.authorCozen, Wendy
dc.contributor.authorBrown, Elizabeth E
dc.contributor.authorSuska, Anna
dc.contributor.authorHaastrup, Eva K
dc.contributor.authorOrlowski, Robert Z
dc.contributor.authorDudziński, Marek
dc.contributor.authorGarcia-Sanz, Ramon
dc.contributor.authorKruszewski, Marcin
dc.contributor.authorMartinez-Lopez, Joaquin
dc.contributor.authorBeider, Katia
dc.contributor.authorIskierka-Jazdzewska, Elżbieta
dc.contributor.authorPelosini, Matteo
dc.contributor.authorBerndt, Sonja I
dc.contributor.authorRaźny, Małgorzata
dc.contributor.authorJamroziak, Krzysztof
dc.contributor.authorRajkumar, S Vincent
dc.contributor.authorJurczyszyn, Artur
dc.contributor.authorVangsted, Annette Juul
dc.contributor.authorCollado, Pilar Garrido
dc.contributor.authorVogel, Ulla
dc.contributor.authorHofmann, Jonathan N
dc.contributor.authorPetrini, Mario
dc.contributor.authorButrym, Aleksandra
dc.contributor.authorSlager, Susan L
dc.contributor.authorZiv, Elad
dc.contributor.authorSubocz, Edyta
dc.contributor.authorGiles, Graham G
dc.contributor.authorAndersen, Niels Frost
dc.contributor.authorMazur, Grzegorz
dc.contributor.authorWatek, Marzena
dc.contributor.authorLesueur, Fabienne
dc.contributor.authorHildebrandt, Michelle A T
dc.contributor.authorZawirska, Daria
dc.contributor.authorEbbesen, Lene Hyldahl
dc.contributor.authorMarques, Herlander
dc.contributor.authorGemignani, Federica
dc.contributor.authorDumontet, Charles
dc.contributor.authorVárkonyi, Judit
dc.contributor.authorBuda, Gabriele
dc.contributor.authorNagler, Arnon
dc.contributor.authorDruzd-Sitek, Agnieszka
dc.contributor.authorWu, Xifeng
dc.contributor.authorKadar, Katalin
dc.contributor.authorCamp, Nicola J
dc.contributor.authorGrzasko, Norbert
dc.contributor.authorWaller, Rosalie G
dc.contributor.authorVachon, Celine
dc.contributor.authorCanzian, Federico
dc.contributor.authorCampa, Daniele
dc.date.accessioned2023-05-03T14:51:33Z
dc.date.available2023-05-03T14:51:33Z
dc.date.issued2022-10-01
dc.description.abstractPleiotropy, which consists of a single gene or allelic variant affecting multiple unrelated traits, is common across cancers, with evidence for genome-wide significant loci shared across cancer and noncancer traits. This feature is particularly relevant in multiple myeloma (MM) because several susceptibility loci that have been identified to date are pleiotropic. Therefore, the aim of this study was to identify novel pleiotropic variants involved in MM risk using 28 684 independent single nucleotide polymorphisms (SNPs) from GWAS Catalog that reached a significant association (P 
dc.identifier.doi10.1002/ijc.34278
dc.identifier.essn1097-0215
dc.identifier.pmcPMC9828677
dc.identifier.pmid36082445
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828677/pdf
dc.identifier.unpaywallURLhttps://findresearcher.sdu.dk/ws/files/219032255/Intl_Journal_of_Cancer_2022_Dicanio_A_pleiotropic_variant_in_DNAJB4_is_associated_with_multiple_myeloma_risk.pdf
dc.identifier.urihttp://hdl.handle.net/10668/22106
dc.issue.number2
dc.journal.titleInternational journal of cancer
dc.journal.titleabbreviationInt J Cancer
dc.language.isoen
dc.organizationHospital Universitario Virgen de las Nieves
dc.organizationCentro Pfizer-Universidad de Granada-Junta de Andalucía de Genómica e Investigación Oncológica-GENYO
dc.page.number239-248
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectgenetic susceptibility
dc.subjectmultiple myeloma
dc.subjectpleiotropy
dc.subjectpleiotropy scan
dc.subjectpolymorphisms
dc.subject.meshHumans
dc.subject.meshMultiple Myeloma
dc.subject.meshOncogenes
dc.subject.meshAlleles
dc.subject.meshPhenotype
dc.subject.meshPolymorphism, Single Nucleotide
dc.subject.meshGenome-Wide Association Study
dc.subject.meshGenetic Predisposition to Disease
dc.subject.meshHSP40 Heat-Shock Proteins
dc.subject.meshDNA-Binding Proteins
dc.subject.meshRNA-Binding Proteins
dc.titleA pleiotropic variant in DNAJB4 is associated with multiple myeloma risk.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number152
dspace.entity.typePublication

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