Publication: Genome-Wide Association Study of White Blood Cell Counts in Patients With Ischemic Stroke.
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Date
2019-10-07
Authors
Torres-Aguila, Nuria P
Carrera, Caty
Giese, Anne-Katrine
Cullell, Natalia
Muiño, Elena
Cárcel-Márquez, Jara
Gallego-Fabrega, Cristina
González-Sánchez, Jonathan
Del Mar Freijo, María
Álvarez-Sabín, José
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Abstract
Background and Purpose- Immune cells play a key role in the first 24h poststroke (acute phase), being associated with stroke outcome. We aimed to find genetic risk factors associated with leukocyte counts during the acute phase of stroke. Methods- Ischemic stroke patients with leukocyte counts data during the first 24h were included. Genome-wide association study and gene expression studies were performed. Results- Our genome-wide association study, which included 2064 (Discovery) and 407 (Replication) patients, revealed a new locus (14q24.3) associated with leukocyte counts. After Joint analysis (n=2471) 5 more polymorphisms reached genome-wide significance (P
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MeSH Terms
Aged
Aged, 80 and over
Brain Ischemia
Chromosomes, Human, Pair 14
Female
Genome-Wide Association Study
Humans
Leukocyte Count
Leukocytes
Male
Middle Aged
Polymorphism, Single Nucleotide
Prognosis
Stroke
Aged, 80 and over
Brain Ischemia
Chromosomes, Human, Pair 14
Female
Genome-Wide Association Study
Humans
Leukocyte Count
Leukocytes
Male
Middle Aged
Polymorphism, Single Nucleotide
Prognosis
Stroke
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Keywords
genome-wide association study, humans, leukocytes, risk factors, stroke