RT Journal Article
T1 Genome-Wide Association Study of White Blood Cell Counts in Patients With Ischemic Stroke.
A1 Torres-Aguila, Nuria P
A1 Carrera, Caty
A1 Giese, Anne-Katrine
A1 Cullell, Natalia
A1 Muiño, Elena
A1 Carcel-Marquez, Jara
A1 Gallego-Fabrega, Cristina
A1 Gonzalez-Sanchez, Jonathan
A1 Del-Mar-Freijo, Maria
A1 Alvarez-Sabin, Jose
A1 Molina, Carlos
A1 Ribo, Marc
A1 Jimenez-Conde, Jordi
A1 Roquer, Jaume
A1 Sobrino, Tomas
A1 Campos, Francisco
A1 Castillo, Jose
A1 Muñoz-Narbona, Lucia
A1 Lopez-Cancio, Elena
A1 Davalos, Antoni
A1 Diaz-Navarro, Rosa
A1 Tur, Silvia
A1 Vives-Bauza, Cristofol
A1 Serrano-Heras, Gemma
A1 Segura, Tomas
A1 Krupinski, Jerzy
A1 Delgado-Mederos, Raquel
A1 Marti-Fabregas, Joan
A1 Heitsch, Laura
A1 Ibañez, Laura
A1 Cruchaga, Carlos
A1 Rost, Natalia S
A1 Montaner, Joan
A1 Lee, Jin-Moo
A1 Fernandez-Cadenas, Israel
K1 genome-wide association study
K1 humans
K1 leukocytes
K1 risk factors
K1 stroke
AB Background and Purpose- Immune cells play a key role in the first 24h poststroke (acute phase), being associated with stroke outcome. We aimed to find genetic risk factors associated with leukocyte counts during the acute phase of stroke . Methods - Ischemic stroke patients with leukocyte counts data during the first 24h were included. Genome-wide association study and gene expression studies were performed. Results- Our genome-wide association study , which included 2064 (Discovery) and 407 (Replication) patients , revealed a new locus (14q24.3) associated with leukocyte counts . After Joint analysis (n=2471) 5 more polymorphisms reached genome -wide significance (P<5×10-8). The 14q24.3 locus was associated with acute stroke outcome (rs112809786, P=0.036) and with ACOT1 and PTGR2  gene expression . Previous polymorphisms associated with leukocyte counts in general- population did not show any significance in our study. Conclusions- We have found the first locus associated with leukocyte counts in ischemic stroke , also associated with acute outcome. Genetic analysis of acute endophenotypes could be useful to find the genetic factors associated with stroke outcome. Our findings suggested a different modulation of immune cells in stroke compared with healthy conditions.
PB Lippincott Williams & Wilkins
YR 2019
FD 2019-10-07
LK http://hdl.handle.net/10668/14589
UL http://hdl.handle.net/10668/14589
LA en
NO Torres-Aguila NP, Carrera C, Giese AK, Cullell N, Muiño E, Cárcel-Márquez J, et al. Genome-Wide Association Study of White Blood Cell Counts in Patients With Ischemic Stroke. Stroke. 2019 Dec;50(12):3618-3621.
DS RISalud
RD Aug 5, 2025