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Genome-Wide Association Study of White Blood Cell Counts in Patients With Ischemic Stroke.

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dc.contributor.authorTorres-Aguila, Nuria P
dc.contributor.authorCarrera, Caty
dc.contributor.authorGiese, Anne-Katrine
dc.contributor.authorCullell, Natalia
dc.contributor.authorMuiño, Elena
dc.contributor.authorCárcel-Márquez, Jara
dc.contributor.authorGallego-Fabrega, Cristina
dc.contributor.authorGonzález-Sánchez, Jonathan
dc.contributor.authorDel Mar Freijo, María
dc.contributor.authorÁlvarez-Sabín, José
dc.contributor.authorMolina, Carlos
dc.contributor.authorRibó, Marc
dc.contributor.authorJimenez-Conde, Jordi
dc.contributor.authorRoquer, Jaume
dc.contributor.authorSobrino, Tomás
dc.contributor.authorCampos, Francisco
dc.contributor.authorCastillo, José
dc.contributor.authorMuñoz-Narbona, Lucia
dc.contributor.authorLopez-Cancio, Elena
dc.contributor.authorDàvalos, Antoni
dc.contributor.authorDiaz-Navarro, Rosa
dc.contributor.authorTur, Silvia
dc.contributor.authorVives-Bauza, Cristòfol
dc.contributor.authorSerrano-Heras, Gemma
dc.contributor.authorSegura, Tomás
dc.contributor.authorKrupinski, Jerzy
dc.contributor.authorDelgado-Mederos, Raquel
dc.contributor.authorMartí-Fàbregas, Joan
dc.contributor.authorHeitsch, Laura
dc.contributor.authorIbañez, Laura
dc.contributor.authorCruchaga, Carlos
dc.contributor.authorRost, Natalia S
dc.contributor.authorMontaner, Joan
dc.contributor.authorLee, Jin-Moo
dc.contributor.authorFernandez-Cadenas, Israel
dc.date.accessioned2023-01-25T13:43:10Z
dc.date.available2023-01-25T13:43:10Z
dc.date.issued2019-10-07
dc.description.abstractBackground and Purpose- Immune cells play a key role in the first 24h poststroke (acute phase), being associated with stroke outcome. We aimed to find genetic risk factors associated with leukocyte counts during the acute phase of stroke. Methods- Ischemic stroke patients with leukocyte counts data during the first 24h were included. Genome-wide association study and gene expression studies were performed. Results- Our genome-wide association study, which included 2064 (Discovery) and 407 (Replication) patients, revealed a new locus (14q24.3) associated with leukocyte counts. After Joint analysis (n=2471) 5 more polymorphisms reached genome-wide significance (P
dc.identifier.doi10.1161/STROKEAHA.119.026593
dc.identifier.essn1524-4628
dc.identifier.pmcPMC6878188
dc.identifier.pmid31587654
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878188/pdf
dc.identifier.unpaywallURLhttps://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.119.026593
dc.identifier.urihttp://hdl.handle.net/10668/14589
dc.issue.number12
dc.journal.titleStroke
dc.journal.titleabbreviationStroke
dc.language.isoen
dc.organizationInstituto de Biomedicina de Sevilla-IBIS
dc.organizationHospital Universitario Virgen del Rocío
dc.organizationHospital Universitario Virgen Macarena
dc.page.number3618-3621
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, N.I.H., Extramural
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.rights.accessRightsopen access
dc.subjectgenome-wide association study
dc.subjecthumans
dc.subjectleukocytes
dc.subjectrisk factors
dc.subjectstroke
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshBrain Ischemia
dc.subject.meshChromosomes, Human, Pair 14
dc.subject.meshFemale
dc.subject.meshGenome-Wide Association Study
dc.subject.meshHumans
dc.subject.meshLeukocyte Count
dc.subject.meshLeukocytes
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPolymorphism, Single Nucleotide
dc.subject.meshPrognosis
dc.subject.meshStroke
dc.titleGenome-Wide Association Study of White Blood Cell Counts in Patients With Ischemic Stroke.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number50
dspace.entity.typePublication

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Instituto de Investigación Biomédica de Sevilla (IBIS)
SAS - Hospital Universitario Virgen del Rocío
SAS - Hospital Universitario Virgen Macarena

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