Publication: Maraviroc contributes to the restoration of the homeostasis of regulatory T-cell subsets in antiretroviral-naive HIV-infected subjects.
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2016-01-22
Authors
Pozo-Balado, M M
Rosado-Sánchez, I
Méndez-Lagares, G
Rodríguez-Méndez, M M
Ruiz-Mateos, E
Benhnia, M R
Muñoz-Fernández, M A
Leal, M
Pacheco, Y M
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Abstract
Regulatory T (Treg) cells comprise different functional subsets with different CCR5 expression. Treg homeostasis is disrupted by HIV but the effect of treatment has barely been explored. In a longitudinal design, we compared the effect of a maraviroc-containing (n = 9) or sparing (n = 12) therapy in antiretroviral-naive HIV-positive participants on peripheral FoxP3(low) CD45RA(+) (nTreg), FoxP3(high) CD45RA(-) (eTreg) and FoxP3(low) CD45RA(-) (non-Treg) cells. Maraviroc significantly reduced all subsets in the short-term and, except for nTreg cells, also normalized them in the long-term. The correlation between eTreg cells and CD4 counts, lost before treatment, was only restored by maraviroc. The differential effect of maraviroc on Treg subsets contributes to understanding its immunomodulatory effects.
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MeSH Terms
CCR5 Receptor Antagonists
CD4 Lymphocyte Count
Cyclohexanes
Forkhead Transcription Factors
HIV Infections
Homeostasis
Humans
Immunophenotyping
Leukocyte Common Antigens
Longitudinal Studies
Maraviroc
T-Lymphocyte Subsets
T-Lymphocytes, Regulatory
Triazoles
CD4 Lymphocyte Count
Cyclohexanes
Forkhead Transcription Factors
HIV Infections
Homeostasis
Humans
Immunophenotyping
Leukocyte Common Antigens
Longitudinal Studies
Maraviroc
T-Lymphocyte Subsets
T-Lymphocytes, Regulatory
Triazoles
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Keywords
CCR5, HIV, Regulatory T-cells, effector-Treg, homeostasis, maraviroc, naive-Treg, non-Treg