RT Journal Article
T1 Maraviroc contributes to the restoration of the homeostasis of regulatory T-cell subsets in antiretroviral-naive HIV-infected subjects.
A1 Pozo-Balado, M M
A1 Rosado-Sanchez, I
A1 Mendez-Lagares, G
A1 Rodriguez-Mendez, M M
A1 Ruiz-Mateos, E
A1 Benhnia, M R
A1 Muñoz-Fernandez, M A
A1 Leal, M
A1 Pacheco, Y M
K1 CCR5
K1 HIV
K1 Regulatory T-cells
K1 effector-Treg
K1 homeostasis
K1 maraviroc
K1 naive-Treg
K1 non-Treg
AB Regulatory T (Treg) cells comprise different functional subsets with different CCR5 expression. Treg homeostasis is disrupted by HIV but the effect of treatment has barely been explored. In a longitudinal design, we compared the effect of a maraviroc-containing (n = 9) or sparing (n = 12) therapy in antiretroviral-naive HIV-positive participants on peripheral FoxP3(low) CD45RA(+) (nTreg), FoxP3(high) CD45RA(-) (eTreg) and FoxP3(low) CD45RA(-) (non-Treg) cells. Maraviroc significantly reduced all subsets in the short-term and, except for nTreg cells, also normalized them in the long-term. The correlation between eTreg cells and CD4 counts, lost before treatment, was only restored by maraviroc. The differential effect of maraviroc on Treg subsets contributes to understanding its immunomodulatory effects.
PB Elsevier Ltd
YR 2016
FD 2016-01-22
LK http://hdl.handle.net/10668/9764
UL http://hdl.handle.net/10668/9764
LA en
NO Pozo-Balado MM, Rosado-Sánchez I, Méndez-Lagares G, Rodríguez-Méndez MM, Ruiz-Mateos E, Benhnia MR, et al. Maraviroc contributes to the restoration of the homeostasis of regulatory T-cell subsets in antiretroviral-naive HIV-infected subjects. Clin Microbiol Infect. 2016 May;22(5):461.e1-5.
DS RISalud
RD Oct 20, 2025