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Maraviroc contributes to the restoration of the homeostasis of regulatory T-cell subsets in antiretroviral-naive HIV-infected subjects.

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dc.contributor.authorPozo-Balado, M M
dc.contributor.authorRosado-Sanchez, I
dc.contributor.authorMendez-Lagares, G
dc.contributor.authorRodriguez-Mendez, M M
dc.contributor.authorRuiz-Mateos, E
dc.contributor.authorBenhnia, M R
dc.contributor.authorMuñoz-Fernandez, M A
dc.contributor.authorLeal, M
dc.contributor.authorPacheco, Y M
dc.contributor.funderFondo de Investigación Sanitaria
dc.contributor.funderSpanish AIDS Research Network of Excellence
dc.contributor.funderMinisterio de Sanidad, Política Social e Igualdad
dc.contributor.funderFundación Progreso y Salud
dc.contributor.funderPfizer/ViiV Healthcare
dc.date.accessioned2023-01-25T08:30:41Z
dc.date.available2023-01-25T08:30:41Z
dc.date.issued2016-01-22
dc.description.abstractRegulatory T (Treg) cells comprise different functional subsets with different CCR5 expression. Treg homeostasis is disrupted by HIV but the effect of treatment has barely been explored. In a longitudinal design, we compared the effect of a maraviroc-containing (n = 9) or sparing (n = 12) therapy in antiretroviral-naive HIV-positive participants on peripheral FoxP3(low) CD45RA(+) (nTreg), FoxP3(high) CD45RA(-) (eTreg) and FoxP3(low) CD45RA(-) (non-Treg) cells. Maraviroc significantly reduced all subsets in the short-term and, except for nTreg cells, also normalized them in the long-term. The correlation between eTreg cells and CD4 counts, lost before treatment, was only restored by maraviroc. The differential effect of maraviroc on Treg subsets contributes to understanding its immunomodulatory effects.
dc.description.versionSi
dc.identifier.citationPozo-Balado MM, Rosado-Sánchez I, Méndez-Lagares G, Rodríguez-Méndez MM, Ruiz-Mateos E, Benhnia MR, et al. Maraviroc contributes to the restoration of the homeostasis of regulatory T-cell subsets in antiretroviral-naive HIV-infected subjects. Clin Microbiol Infect. 2016 May;22(5):461.e1-5.
dc.identifier.doi10.1016/j.cmi.2015.12.025
dc.identifier.essn1469-0691
dc.identifier.pmid26806257
dc.identifier.unpaywallURLhttp://www.clinicalmicrobiologyandinfection.com/article/S1198743X16000185/pdf
dc.identifier.urihttp://hdl.handle.net/10668/9764
dc.issue.number5
dc.journal.titleClinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
dc.journal.titleabbreviationClin Microbiol Infect
dc.language.isoen
dc.organizationInstituto de Biomedicina de Sevilla-IBIS
dc.organizationHospital Universitario Virgen del Rocío
dc.page.number461.e1-461.e5
dc.provenanceRealizada la curación de contenido 11/06/2025.
dc.publisherElsevier Ltd
dc.pubmedtypeJournal Article
dc.relation.projectIDRD12/0017/0029
dc.relation.projectIDRD12/0017/0037
dc.relation.projectIDP11/02014
dc.relation.projectIDEC11-520
dc.relation.projectIDPI-0081-2011
dc.relation.projectIDWS843473
dc.relation.projectIDWS2425049
dc.relation.publisherversionhttps://linkinghub.elsevier.com/retrieve/pii/S1198-743X(16)00018-5
dc.rights.accessRightsRestricted Access
dc.subjectCCR5
dc.subjectHIV
dc.subjectRegulatory T-cells
dc.subjecteffector-Treg
dc.subjecthomeostasis
dc.subjectmaraviroc
dc.subjectnaive-Treg
dc.subjectnon-Treg
dc.subject.decsCélulas
dc.subject.decsMaraviroc
dc.subject.decsTerapéutica
dc.subject.decsVIH
dc.subject.decsComprensión
dc.subject.decsHomeostasis
dc.subject.decsRecuento de linfocito CD4
dc.subject.meshCCR5 Receptor Antagonists
dc.subject.meshCD4 Lymphocyte Count
dc.subject.meshCyclohexanes
dc.subject.meshForkhead Transcription Factors
dc.subject.meshHIV Infections
dc.subject.meshHomeostasis
dc.subject.meshHumans
dc.subject.meshImmunophenotyping
dc.subject.meshLeukocyte Common Antigens
dc.subject.meshLongitudinal Studies
dc.subject.meshMaraviroc
dc.subject.meshT-Lymphocyte Subsets
dc.subject.meshT-Lymphocytes, Regulatory
dc.subject.meshTriazoles
dc.titleMaraviroc contributes to the restoration of the homeostasis of regulatory T-cell subsets in antiretroviral-naive HIV-infected subjects.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number22
dspace.entity.typePublication

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