Publication: Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status.
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Identifiers
Date
2019-04-25
Authors
Fedirko, Veronika
Jenab, Mazda
Méplan, Catherine
Jones, Jeb S
Zhu, Wanzhe
Schomburg, Lutz
Siddiq, Afshan
Hybsier, Sandra
Overvad, Kim
Tjønneland, Anne
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
MPDI
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Abstract
Selenoprotein genetic variations and suboptimal selenium (Se) levels may contribute to the risk of colorectal cancer (CRC) development. We examined the association between CRC risk and genotype for single nucleotide polymorphisms (SNPs) in selenoprotein and Se metabolic pathway genes. Illumina Goldengate assays were designed and resulted in the genotyping of 1040 variants in 154 genes from 1420 cases and 1421 controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Multivariable logistic regression revealed an association of 144 individual SNPs from 63 Se pathway genes with CRC risk. However, regarding the selenoprotein genes, only TXNRD1 rs11111979 retained borderline statistical significance after adjustment for correlated tests (PACT = 0.10; PACT significance threshold was P
Description
MeSH Terms
Adult
Aged
Cohort Studies
Colorectal Neoplasms
Female
Gene Expression Regulation
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Nutritional Status
Polymorphism, Single Nucleotide
Prospective Studies
Selenium
Selenoproteins
Aged
Cohort Studies
Colorectal Neoplasms
Female
Gene Expression Regulation
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Nutritional Status
Polymorphism, Single Nucleotide
Prospective Studies
Selenium
Selenoproteins
DeCS Terms
Biomarcadores
Selenio
Neoplasias Colorrectales
Selenio
Neoplasias Colorrectales
CIE Terms
Keywords
biomarkers, colorectal cancer risk, colorectal neoplasms, genetic epidemiology, prospective cohort, selenium, selenium pathway, selenium status, selenoprotein P, selenoprotein gene variation
Citation
Fedirko V, Jenab M, Méplan C, Jones JS, Zhu W, Schomburg L, et al. Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status. Nutrients. 2019 Apr 25;11(4):935.