RT Journal Article
T1 Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status.
A1 Fedirko, Veronika
A1 Jenab, Mazda
A1 Méplan, Catherine
A1 Jones, Jeb S
A1 Zhu, Wanzhe
A1 Schomburg, Lutz
A1 Siddiq, Afshan
A1 Hybsier, Sandra
A1 Overvad, Kim
A1 Tjønneland, Anne
A1 Omichessan, Hanane
A1 Perduca, Vittorio
A1 Boutron-Ruault, Marie-Christine
A1 Kühn, Tilman
A1 Katzke, Verena
A1 Aleksandrova, Krasimira
A1 Trichopoulou, Antonia
A1 Karakatsani, Anna
A1 Kotanidou, Anastasia
A1 Tumino, Rosario
A1 Panico, Salvatore
A1 Masala, Giovanna
A1 Agnoli, Claudia
A1 Naccarati, Alessio
A1 Bueno-de-Mesquita, Bas
A1 Vermeulen, Roel C H
A1 Weiderpass, Elisabete
A1 Skeie, Guri
A1 Nøst, Therese Haugdahl
A1 Lujan-Barroso, Leila
A1 Quirós, J Ramón
A1 Huerta, José María
A1 Rodríguez-Barranco, Miguel
A1 Barricarte, Aurelio
A1 Gylling, Björn
A1 Harlid, Sophia
A1 Bradbury, Kathryn E
A1 Wareham, Nick
A1 Khaw, Kay-Tee
A1 Gunter, Marc
A1 Murphy, Neil
A1 Freisling, Heinz
A1 Tsilidis, Kostas
A1 Aune, Dagfinn
A1 Riboli, Elio
A1 Hesketh, John E
A1 Hughes, David J
K1 biomarkers
K1 colorectal cancer risk
K1 colorectal neoplasms
K1 genetic epidemiology
K1 prospective cohort
K1 selenium
K1 selenium pathway
K1 selenium status
K1 selenoprotein P
K1 selenoprotein gene variation
AB Selenoprotein genetic variations and suboptimal selenium (Se) levels may contribute to the risk of colorectal cancer (CRC) development. We examined the association between CRC risk and genotype for single nucleotide polymorphisms (SNPs) in selenoprotein and Se metabolic pathway genes. Illumina Goldengate assays were designed and resulted in the genotyping of 1040 variants in 154 genes from 1420 cases and 1421 controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Multivariable logistic regression revealed an association of 144 individual SNPs from 63 Se pathway genes with CRC risk. However, regarding the selenoprotein genes, only TXNRD1 rs11111979 retained borderline statistical significance after adjustment for correlated tests (PACT = 0.10; PACT significance threshold was P
PB MPDI
YR 2019
FD 2019-04-25
LK http://hdl.handle.net/10668/13879
UL http://hdl.handle.net/10668/13879
LA en
NO Fedirko V, Jenab M, Méplan C, Jones JS, Zhu W, Schomburg L, et al. Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status. Nutrients. 2019 Apr 25;11(4):935.
DS RISalud
RD Apr 7, 2025