Publication:
Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status.

Simple item page
dc.contributor.authorFedirko, Veronika
dc.contributor.authorJenab, Mazda
dc.contributor.authorMéplan, Catherine
dc.contributor.authorJones, Jeb S
dc.contributor.authorZhu, Wanzhe
dc.contributor.authorSchomburg, Lutz
dc.contributor.authorSiddiq, Afshan
dc.contributor.authorHybsier, Sandra
dc.contributor.authorOvervad, Kim
dc.contributor.authorTjønneland, Anne
dc.contributor.authorOmichessan, Hanane
dc.contributor.authorPerduca, Vittorio
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorKühn, Tilman
dc.contributor.authorKatzke, Verena
dc.contributor.authorAleksandrova, Krasimira
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorKarakatsani, Anna
dc.contributor.authorKotanidou, Anastasia
dc.contributor.authorTumino, Rosario
dc.contributor.authorPanico, Salvatore
dc.contributor.authorMasala, Giovanna
dc.contributor.authorAgnoli, Claudia
dc.contributor.authorNaccarati, Alessio
dc.contributor.authorBueno-de-Mesquita, Bas
dc.contributor.authorVermeulen, Roel C H
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorSkeie, Guri
dc.contributor.authorNøst, Therese Haugdahl
dc.contributor.authorLujan-Barroso, Leila
dc.contributor.authorQuirós, J Ramón
dc.contributor.authorHuerta, José María
dc.contributor.authorRodríguez-Barranco, Miguel
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorGylling, Björn
dc.contributor.authorHarlid, Sophia
dc.contributor.authorBradbury, Kathryn E
dc.contributor.authorWareham, Nick
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorGunter, Marc
dc.contributor.authorMurphy, Neil
dc.contributor.authorFreisling, Heinz
dc.contributor.authorTsilidis, Kostas
dc.contributor.authorAune, Dagfinn
dc.contributor.authorRiboli, Elio
dc.contributor.authorHesketh, John E
dc.contributor.authorHughes, David J
dc.date.accessioned2023-01-25T13:32:57Z
dc.date.available2023-01-25T13:32:57Z
dc.date.issued2019-04-25
dc.description.abstractSelenoprotein genetic variations and suboptimal selenium (Se) levels may contribute to the risk of colorectal cancer (CRC) development. We examined the association between CRC risk and genotype for single nucleotide polymorphisms (SNPs) in selenoprotein and Se metabolic pathway genes. Illumina Goldengate assays were designed and resulted in the genotyping of 1040 variants in 154 genes from 1420 cases and 1421 controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Multivariable logistic regression revealed an association of 144 individual SNPs from 63 Se pathway genes with CRC risk. However, regarding the selenoprotein genes, only TXNRD1 rs11111979 retained borderline statistical significance after adjustment for correlated tests (PACT = 0.10; PACT significance threshold was P
dc.description.versionSi
dc.identifier.citationFedirko V, Jenab M, Méplan C, Jones JS, Zhu W, Schomburg L, et al. Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status. Nutrients. 2019 Apr 25;11(4):935.
dc.identifier.doi10.3390/nu11040935
dc.identifier.essn2072-6643
dc.identifier.pmcPMC6520820
dc.identifier.pmid31027226
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520820/pdf
dc.identifier.unpaywallURLhttps://www.mdpi.com/2072-6643/11/4/935/pdf?version=1556183357
dc.identifier.urihttp://hdl.handle.net/10668/13879
dc.issue.number4
dc.journal.titleNutrients
dc.journal.titleabbreviationNutrients
dc.language.isoen
dc.organizationEscuela Andaluza de Salud Pública-EASP
dc.organizationHospital Universitario San Cecilio
dc.publisherMPDI
dc.pubmedtypeJournal Article
dc.pubmedtypeMulticenter Study
dc.relation.publisherversionhttps://www.mdpi.com/2072-6643/11/4/935
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectbiomarkers
dc.subjectcolorectal cancer risk
dc.subjectcolorectal neoplasms
dc.subjectgenetic epidemiology
dc.subjectprospective cohort
dc.subjectselenium
dc.subjectselenium pathway
dc.subjectselenium status
dc.subjectselenoprotein P
dc.subjectselenoprotein gene variation
dc.subject.decsBiomarcadores
dc.subject.decsSelenio
dc.subject.decsNeoplasias Colorrectales
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshCohort Studies
dc.subject.meshColorectal Neoplasms
dc.subject.meshFemale
dc.subject.meshGene Expression Regulation
dc.subject.meshGenetic Predisposition to Disease
dc.subject.meshGenotype
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNutritional Status
dc.subject.meshPolymorphism, Single Nucleotide
dc.subject.meshProspective Studies
dc.subject.meshSelenium
dc.subject.meshSelenoproteins
dc.titleAssociation of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number11
dspace.entity.typePublication
person.affiliation.name[Rodriguez-Barranco,M] Andalucia School of Public Health, Granada, Spain
person.affiliation.nameInstitute for Biosanitary Research, Granada, Spain

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Fedirko_Association.pdf
Size:
316.56 KB
Format:
Adobe Portable Document Format
Download

Collections

Escuela Andaluza de Salud Pública
Instituto de Investigación Biosanitaria de Granada (ibsGRANADA)

© 2023 – Repositorio Institucional de Salud de Andalucía - Fundación Pública Andaluza Progreso y Salud - Consejería de Salud y Consumo de la Junta de Andalucía