Publication: Melatonin and Nitrones As Potential Therapeutic Agents for Stroke.
No Thumbnail Available
Identifiers
Date
2016-11-23
Authors
Romero, Alejandro
Ramos, Eva
Patiño, Paloma
Oset-Gasque, Maria J
Lopez-Muñoz, Francisco
Marco-Contelles, Jose
Ayuso, María I
Alcazar, Alberto
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Frontiers Research Foundation
Abstract
Stroke is a disease of aging affecting millions of people worldwide, and recombinant tissue-type plasminogen activator (r-tPA) is the only treatment approved. However, r-tPA has a low therapeutic window and secondary effects which limit its beneficial outcome, urging thus the search for new more efficient therapies . Among them, neuroprotection based on melatonin or nitrones, as free radical traps, have arisen as drug candidates due to their strong antioxidant power . In this Perspective article, an update on the specific results of the melatonin and several new nitrones are presented.
Description
MeSH Terms
Tissue Plasminogen Activator
Antioxidants
Melatonin
nitrones
Neuroprotection
Stroke
Aging
Free Radicals
Antioxidants
Melatonin
nitrones
Neuroprotection
Stroke
Aging
Free Radicals
DeCS Terms
Terapéutica
Melatonina
Enfermedad
Antioxidantes
Radicales Libres
Envejecimiento
Neuroprotección
Melatonina
Enfermedad
Antioxidantes
Radicales Libres
Envejecimiento
Neuroprotección
CIE Terms
Keywords
melatonin, neuroprotection, nitrones, oxidative stress, stroke
Citation
Romero A, Ramos E, Patiño P, Oset-Gasque MJ, López-Muñoz F, Marco-Contelles J, et al. Melatonin and Nitrones As Potential Therapeutic Agents for Stroke. Front Aging Neurosci. 2016 Nov 23;8:281.