Publication:
Melatonin and Nitrones As Potential Therapeutic Agents for Stroke.

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Date

2016-11-23

Authors

Romero, Alejandro
Ramos, Eva
Patiño, Paloma
Oset-Gasque, Maria J
Lopez-Muñoz, Francisco
Marco-Contelles, Jose
Ayuso, María I
Alcazar, Alberto

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Frontiers Research Foundation
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Abstract

Stroke is a disease of aging affecting millions of people worldwide, and recombinant tissue-type plasminogen activator (r-tPA) is the only treatment approved. However, r-tPA has a low therapeutic window and secondary effects which limit its beneficial outcome, urging thus the search for new more efficient therapies . Among them, neuroprotection based on melatonin or nitrones, as free radical traps, have arisen as drug candidates due to their strong antioxidant power . In this Perspective article, an update on the specific results of the melatonin and several new nitrones are presented.

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MeSH Terms

Tissue Plasminogen Activator
Antioxidants
Melatonin
nitrones
Neuroprotection
Stroke
Aging
Free Radicals

DeCS Terms

Terapéutica
Melatonina
Enfermedad
Antioxidantes
Radicales Libres
Envejecimiento
Neuroprotección

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Keywords

melatonin, neuroprotection, nitrones, oxidative stress, stroke

Citation

Romero A, Ramos E, Patiño P, Oset-Gasque MJ, López-Muñoz F, Marco-Contelles J, et al. Melatonin and Nitrones As Potential Therapeutic Agents for Stroke. Front Aging Neurosci. 2016 Nov 23;8:281.