RT Journal Article
T1 Melatonin and Nitrones As Potential Therapeutic Agents for Stroke.
A1 Romero, Alejandro
A1 Ramos, Eva
A1 Patiño, Paloma
A1 Oset-Gasque, Maria J
A1 Lopez-Muñoz, Francisco
A1 Marco-Contelles, Jose
A1 Ayuso, María I
A1 Alcazar, Alberto
K1 melatonin
K1 neuroprotection
K1 nitrones
K1 oxidative stress
K1 stroke
AB Stroke is a disease of aging affecting millions of people worldwide, and recombinant tissue-type plasminogen activator (r-tPA) is the only treatment approved. However, r-tPA has a low therapeutic window and secondary effects which limit its beneficial outcome, urging thus the search for new more efficient therapies . Among them, neuroprotection based on melatonin or nitrones, as free radical traps, have arisen as drug candidates due to their strong antioxidant power . In this Perspective article, an update on the specific results of the melatonin and several new nitrones are presented.
PB Frontiers Research Foundation
SN 1663-4365
YR 2016
FD 2016-11-23
LK http://hdl.handle.net/10668/11259
UL http://hdl.handle.net/10668/11259
LA en
NO Romero A, Ramos E, Patiño P, Oset-Gasque MJ, López-Muñoz F, Marco-Contelles J, et al. Melatonin and Nitrones As Potential Therapeutic Agents for Stroke. Front Aging Neurosci. 2016 Nov 23;8:281.
DS RISalud
RD Jul 5, 2025