%0 Journal Article
%A Romero, Alejandro
%A Ramos, Eva
%A Patiño, Paloma
%A Oset-Gasque, Maria J
%A Lopez-Muñoz, Francisco
%A Marco-Contelles, Jose
%A Ayuso, María I
%A Alcazar, Alberto
%T Melatonin and Nitrones As Potential Therapeutic Agents for Stroke.
%D 2016
%@ 1663-4365
%U http://hdl.handle.net/10668/11259
%X Stroke is a disease of aging affecting millions of people worldwide, and recombinant tissue-type plasminogen activator (r-tPA) is the only treatment approved. However, r-tPA has a low therapeutic window and secondary effects which limit its beneficial outcome, urging thus the search for new more efficient therapies . Among them, neuroprotection based on melatonin or nitrones, as free radical traps, have arisen as drug candidates due to their strong antioxidant power . In this Perspective article, an update on the specific results of the melatonin and several new nitrones are presented.
%K melatonin
%K neuroprotection
%K nitrones
%K oxidative stress
%K stroke
%~