Obstetric outcomes in pregnant women diagnosed of antiphospholipid syndrome

Abstract

Introduction; The antiphospholipid syndrome (APS) is an autoinmune disease characterized by the occurence of thrombosis, obstetric morbidity and the presence of antiphospholipid antibodies. The aim of this study was to evaluate the obstetric outcomes in pregnant women diagnosed of antiphospholipid syndrome, as well as examine the conditions which may influence in those results.Materials and methods: A retrospective study was undertaken with pregnant women diagnosed of APS, who were attended in our hospital between 2007 and 2017.Results: During the period of study 35 patients with APS and a sum of 50 pregnancies were gathered. Heparin was used in ail pregnancies and acetylsalicylic acid in 96%. Any adverse obstetric outcome occurred in 34% of the pregnancies in the study. The triple positivity of antiphospholipid antibodies was associated to higher percentage of premature deliveries. The lupus anticoagulant alone was not related to worse obstetric outcomes.Conclusions: Pregnancy in APS patients means a challenge, requiring a multidisciplinary management by Obstetnaans and Rheumathologists. On the other hand, the antiphospholipid antibodies profile could help to recognize those patient at risk, in order to adequate treatment and improve obstetric results.