In Vitro Activity of Tedizolid against Mycobacterium tuberculosis.

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dc.contributor.authorRuiz, Pilar
dc.contributor.authorCausse, Manuel
dc.contributor.authorVaquero, Manuel
dc.contributor.authorCasal, Manuel
dc.date.accessioned2025-01-07T13:27:56Z
dc.date.available2025-01-07T13:27:56Z
dc.date.issued2019-03-27
dc.description.abstractTedizolid is a novel oxazolidinone with activities against Gram-positive microorganisms, including mycobacteria. We studied the in vitro activity of tedizolid against 120 Mycobacterium tuberculosis strains, including susceptible, first-line-resistant, and multidrug-resistant isolates. MIC was tested using the Bactec 960 MGIT system. MIC90 and MIC50 were 0.5 and 0.25 μg/ml, respectively, in susceptible and resistant strains. Tedizolid may be an alternative in the treatment of resistant M. tuberculosis.
dc.identifier.doi10.1128/AAC.01939-18
dc.identifier.essn1098-6596
dc.identifier.pmcPMC6437524
dc.identifier.pmid30670412
dc.identifier.pubmedURLhttps://pmc.ncbi.nlm.nih.gov/articles/PMC6437524/pdf
dc.identifier.unpaywallURLhttps://aac.asm.org/content/aac/63/4/e01939-18.full.pdf
dc.identifier.urihttps://hdl.handle.net/10668/25536
dc.issue.number4
dc.journal.titleAntimicrobial agents and chemotherapy
dc.journal.titleabbreviationAntimicrob Agents Chemother
dc.language.isoen
dc.organizationSAS - Hospital Universitario Reina Sofía
dc.organizationInstituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.rights.accessRightsopen access
dc.subjectMycobacterium tuberculosis
dc.subjectresistance
dc.subjecttedizolid
dc.subject.meshAnti-Bacterial Agents
dc.subject.meshDrug Resistance, Multiple, Bacterial
dc.subject.meshHumans
dc.subject.meshMicrobial Sensitivity Tests
dc.subject.meshMycobacterium tuberculosis
dc.subject.meshOxazolidinones
dc.subject.meshTetrazoles
dc.subject.meshTuberculosis
dc.titleIn Vitro Activity of Tedizolid against Mycobacterium tuberculosis.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number63

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