In Vitro Activity of Tedizolid against Mycobacterium tuberculosis.
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Date
2019-03-27
Authors
Ruiz, Pilar
Causse, Manuel
Vaquero, Manuel
Casal, Manuel
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Publisher
American Society for Microbiology
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Abstract
Tedizolid is a novel oxazolidinone with activities against Gram-positive microorganisms, including mycobacteria. We studied the in vitro activity of tedizolid against 120 Mycobacterium tuberculosis strains, including susceptible, first-line-resistant, and multidrug-resistant isolates. MIC was tested using the Bactec 960 MGIT system. MIC90 and MIC50 were 0.5 and 0.25 μg/ml, respectively, in susceptible and resistant strains. Tedizolid may be an alternative in the treatment of resistant M. tuberculosis.
Description
MeSH Terms
Anti-Bacterial Agents
Drug Resistance, Multiple, Bacterial
Humans
Microbial Sensitivity Tests
Mycobacterium tuberculosis
Oxazolidinones
Tetrazoles
Tuberculosis
Tedizolid
Drug Resistance, Multiple, Bacterial
Humans
Microbial Sensitivity Tests
Mycobacterium tuberculosis
Oxazolidinones
Tetrazoles
Tuberculosis
Tedizolid
DeCS Terms
Pruebas de sensibilidad microbiana
Técnicas in vitro
Oxazolidinonas
Farmacorresistencia bacteriana
Farmacorresistencia microbiana
Técnicas in vitro
Oxazolidinonas
Farmacorresistencia bacteriana
Farmacorresistencia microbiana
CIE Terms
Keywords
Mycobacterium tuberculosis, Resistance, Tedizolid
Citation
Ruiz P, Causse M, Vaquero M, Casal M. In Vitro Activity of Tedizolid against Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2019 Mar 27;63(4):e01939-18