In Vitro Activity of Tedizolid against Mycobacterium tuberculosis.
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2019-03-27
Authors
Ruiz, Pilar
Causse, Manuel
Vaquero, Manuel
Casal, Manuel
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Abstract
Tedizolid is a novel oxazolidinone with activities against Gram-positive microorganisms, including mycobacteria. We studied the in vitro activity of tedizolid against 120 Mycobacterium tuberculosis strains, including susceptible, first-line-resistant, and multidrug-resistant isolates. MIC was tested using the Bactec 960 MGIT system. MIC90 and MIC50 were 0.5 and 0.25 μg/ml, respectively, in susceptible and resistant strains. Tedizolid may be an alternative in the treatment of resistant M. tuberculosis.
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MeSH Terms
Anti-Bacterial Agents
Drug Resistance, Multiple, Bacterial
Humans
Microbial Sensitivity Tests
Mycobacterium tuberculosis
Oxazolidinones
Tetrazoles
Tuberculosis
Drug Resistance, Multiple, Bacterial
Humans
Microbial Sensitivity Tests
Mycobacterium tuberculosis
Oxazolidinones
Tetrazoles
Tuberculosis
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Keywords
Mycobacterium tuberculosis, resistance, tedizolid