Predictors of Loss of Functional Independence in Parkinson's Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up and Comparison with a Control Group
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2021-10-01
Authors
Santos Garcia, Diego
de Deus Fonticoba, Teresa
Cores Bartolome, Carlos
Naya Rios, Lucia
Garcia Roca, Lucia
Martinez Miro, Cristina
Canfield, Hector
Jesus, Silvia
Aguilar, Miquel
Pastor, Pau
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Mdpi
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Abstract
Background and objective: The aim of this study was to compare the progression of independence in activities of daily living (ADL) in Parkinson's disease (PD) patients versus a control group, as well as to identify predictors of disability progression and functional dependency (FD). Patients and Methods: PD patients and control subjects, who were recruited from 35 centers of Spain from the COPPADIS cohort between January 2016 and November 2017 (V0), were included. Patients and subjects were then evaluated again at the 2-year follow-up (V2). Disability was assessed with the Schwab & England Activities of Daily Living Scale (S&E-ADLS) at V0 and V2. FD was defined as an S&E-ADLS score less than 80%. Results: In the PD group, a significant decrease in the S&E-ADLS score from V0 to V2 (N = 507; from 88.58 +/- 10.19 to 84.26 +/- 13.38; p
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activities of daily living, dependency, disability, gait, Parkinson's disease, Quality-of-life, Nonmotor symptoms, Prognostic-factors, Motor impairment, Disability, Progression, Prevalence, Dependency, Survival, Gait