RT Journal Article
T1 Predictors of Loss of Functional Independence in Parkinson's Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up and Comparison with a Control Group
A1 Santos-Garcia, Diego
A1 de-Deus-Fonticoba, Teresa
A1 Cores-Bartolome, Carlos
A1 Naya-Rios, Lucia
A1 Garcia-Roca, Lucia
A1 Martinez-Miro, Cristina
A1 Canfield, Hector
A1 Jesus, Silvia
A1 Aguilar, Miquel
A1 Pastor, Pau
A1 Cosgaya, Marina
A1 Garcia-Caldentey, Juan
A1 Caballol, Nuria
A1 Legarda, Ines
A1 Hernandez-Vara, Jorge
A1 Cabo, Iria
A1 Lopez-Manzanares, Lydia
A1 Gonzalez Aramburu, Isabel
A1 Avila-Rivera, Maria A.
A1 Gomez-Mayordomo, Victor
A1 Nogueira, Victor
A1 Puente, Victor
A1 Dotor, Julio
A1 Borrue, Carmen
A1 Solano-Vila, Berta
A1 Alvarez-Sauco, Maria
A1 Vela, Lydia
A1 Escalante, Sonia
A1 Cubo, Esther
A1 Carrillo-Padilla, Francisco
A1 Martinez-Castrillo, Juan C.
A1 Sanchez-Alonso, Pilar
A1 Alonso-Losada, Maria G.
A1 Lopez-Ariztegui, Nuria
A1 Gaston, Itziar
A1 Kulisevsky, Jaime
A1 Blazquez-Estrada, Marta
A1 Seijo, Manuel
A1 Ruiz-Martinez, Javier
A1 Valero, Caridad
A1 Kurtis, Monica
A1 de-Fabregues, Oriol
A1 Gonzalez-Ardura, Jessica
A1 Alonso-Redondo, Ruben
A1 Ordas, Carlos
A1 Lopez-Diaz, Luis M.
A1 McAfee, Darrian
A1 Martinez-Martin, Pablo
A1 Mir, Pablo
K1 activities of daily living
K1 Parkinson's disease
K1 Quality-of-life
K1 Nonmotor symptoms
K1 Prognostic-factors
K1 Motor impairment
K1 Disability
K1 Progression
K1 Prevalence
K1 Dependency
K1 Survival
K1 Gait
AB Background and objective: The aim of this study was to compare the progression of independence in activities of daily living ( ADL ) in Parkinson’s disease (PD) patients versus a control group , as well as to identify predictors of disability progression and functional dependency (FD). Patients and Methods : PD patients and control subjects, who were recruited from 35 centers of Spain from the COPPADIS cohort between January 2016 and November 2017 (V0), were included. Patients and subjects were then evaluated again at the 2-year follow-up (V2). Disability was assessed with the Schwab & England Activities of Daily Living Scale (S&E-ADLS) at V0 and V2. FD was defined as an S&E-ADLS score less than 80%. Results: In the PD group, a significant decrease in the S&E-ADLS score from V0 to V2 (N = 507; from 88.58 ± 10.19 to 84.26 ± 13.38; p < 0.0001; Cohen’s effect size = −0.519) was observed but not in controls (N = 124; from 98.87 ± 6.52 to 99.52 ± 2.15; p = 0.238). When only patients considered functional independent at baseline were included, 55 out of 463 (11.9%) converted to functional dependent at V2. To be a female (OR = 2.908; p = 0.009), have longer disease duration (OR = 1.152; p = 0.002), have a non-tremoric motor phenotype at baseline (OR = 3.574; p = 0.004), have a higher score at baseline in FOGQ (OR = 1.244; p < 0.0001) and BDI-II (OR = 1.080; p = 0.008), have a lower score at baseline in PD-CRS (OR = 0.963; p = 0.008), and have a greater increase in the score from V0 to V2 in UPDRS-IV (OR = 1.168; p = 0.0.29), FOGQ (OR = 1.348; p < 0.0001) and VAFS-Mental (OR = 1.177; p = 0.013) (adjusted R-squared 0.52; Hosmer and Lemeshow test = 0.94) were all found to be independent predictors of FD at V2. Conclusions: In conclusion, autonomy for ADL worsens in PD patients compared to controls. Cognitive impairment , gait problems, fatigue , depressive symptoms , more advanced disease , and a non- tremor phenotype are independent predictors of FD in the short-term.
PB MDPI AG
YR 2021
FD 2021-09-29
LK https://hdl.handle.net/10668/27952
UL https://hdl.handle.net/10668/27952
LA en
NO Santos García D, de Deus Fonticoba T, Cores Bartolomé C, Naya Ríos L, García Roca L, Martínez Miró C, et al. Predictors of Loss of Functional Independence in Parkinson's Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up and Comparison with a Control Group. Diagnostics (Basel). 2021 Sep 29;11(10):1801.
DS RISalud
RD Apr 12, 2025