GWAS loci associated with Chagas cardiomyopathy influences DNA methylation levels.
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2021-10-29
Authors
Casares-Marfil, Desiré
Kerick, Martin
Andrés-León, Eduardo
Bosch-Nicolau, Pau
Molina, Israel
Chagas Genetics CYTED Network
Martin, Javier
Acosta-Herrera, Marialbert
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Abstract
A recent genome-wide association study (GWAS) identified a locus in chromosome 11 associated with the chronic cardiac form of Chagas disease. Here we aimed to elucidate the potential functional mechanism underlying this genetic association by analyzing the correlation among single nucleotide polymorphisms (SNPs) and DNA methylation (DNAm) levels as cis methylation quantitative trait loci (cis-mQTL) within this region. A total of 2,611 SNPs were tested against 2,647 DNAm sites, in a subset of 37 chronic Chagas cardiomyopathy patients and 20 asymptomatic individuals from the GWAS. We identified 6,958 significant cis-mQTLs (False Discovery Rate [FDR]
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MeSH Terms
Adult
Aged
Carrier Proteins
Chagas Cardiomyopathy
DNA Methylation
DNA Polymerase I
Female
Genome-Wide Association Study
Humans
Male
Middle Aged
Phospholipases A2, Calcium-Independent
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Repressor Proteins
Tumor Suppressor Proteins
Aged
Carrier Proteins
Chagas Cardiomyopathy
DNA Methylation
DNA Polymerase I
Female
Genome-Wide Association Study
Humans
Male
Middle Aged
Phospholipases A2, Calcium-Independent
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Repressor Proteins
Tumor Suppressor Proteins