RT Journal Article
T1 GWAS loci associated with Chagas cardiomyopathy influences DNA methylation levels.
A1 Casares-Marfil, Desiré
A1 Kerick, Martin
A1 Andrés-León, Eduardo
A1 Bosch-Nicolau, Pau
A1 Molina, Israel
A1 Chagas Genetics CYTED Network, 
A1 Martin, Javier
A1 Acosta-Herrera, Marialbert
AB A recent genome-wide association study (GWAS) identified a locus in chromosome 11 associated with the chronic cardiac form of Chagas disease. Here we aimed to elucidate the potential functional mechanism underlying this genetic association by analyzing the correlation among single nucleotide polymorphisms (SNPs) and DNA methylation (DNAm) levels as cis methylation quantitative trait loci (cis-mQTL) within this region. A total of 2,611 SNPs were tested against 2,647 DNAm sites, in a subset of 37 chronic Chagas cardiomyopathy patients and 20 asymptomatic individuals from the GWAS. We identified 6,958 significant cis-mQTLs (False Discovery Rate [FDR]
YR 2021
FD 2021-10-29
LK https://hdl.handle.net/10668/24675
UL https://hdl.handle.net/10668/24675
LA en
DS RISalud
RD Apr 17, 2025