COPD clinical control as a predictor of future exacerbations: concept validation in the SPARK study population.

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dc.contributor.authorBarrecheguren, Miriam
dc.contributor.authorKostikas, Konstantinos
dc.contributor.authorMezzi, Karen
dc.contributor.authorShen, Steven
dc.contributor.authorAlcazar, Bernardino
dc.contributor.authorSoler-Cataluña, Juan José
dc.contributor.authorMiravitlles, Marc
dc.contributor.authorWedzicha, Jadwiga A
dc.date.accessioned2025-01-07T13:46:05Z
dc.date.available2025-01-07T13:46:05Z
dc.date.issued2020-02-10
dc.description.abstractThe concept of chronic obstructive pulmonary disease (COPD) control has been proposed to guide treatment decisions in COPD. In this study, we aimed to validate the prospective value of this concept in the SPARK study population. Control was assessed based on COPD stability and impact. Patients with low impact and stability during weeks 1-12 were classified as controlled, and exacerbations were measured during a 52-week follow-up. Of the 2044 patients included a majority were non-controlled (80%), frequently due to high impact. During the follow-up, the rate of moderate/severe exacerbations was significantly lower in controlled patients (rate ratio, 0.56, 95% CI 0.48 to 0.65 p
dc.identifier.doi10.1136/thoraxjnl-2018-212752
dc.identifier.essn1468-3296
dc.identifier.pmid32041741
dc.identifier.unpaywallURLhttps://thorax.bmj.com/content/thoraxjnl/75/4/351.full.pdf
dc.identifier.urihttps://hdl.handle.net/10668/25848
dc.issue.number4
dc.journal.titleThorax
dc.journal.titleabbreviationThorax
dc.language.isoen
dc.organizationSAS - Hospital Universitario Reina Sofía
dc.organizationSAS - Hospital Universitario Reina Sofía
dc.organizationInstituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)
dc.page.number351-353
dc.pubmedtypeJournal Article
dc.pubmedtypeMulticenter Study
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.rights.accessRightsopen access
dc.subjectCOPD Exacerbations
dc.subject.meshAged
dc.subject.meshBronchodilator Agents
dc.subject.meshDisease Progression
dc.subject.meshDose-Response Relationship, Drug
dc.subject.meshDouble-Blind Method
dc.subject.meshDrug Administration Schedule
dc.subject.meshDrug Therapy, Combination
dc.subject.meshFemale
dc.subject.meshGlycopyrrolate
dc.subject.meshHumans
dc.subject.meshIndans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshProspective Studies
dc.subject.meshPulmonary Disease, Chronic Obstructive
dc.subject.meshQuinolones
dc.subject.meshReproducibility of Results
dc.subject.meshRespiratory Function Tests
dc.subject.meshRisk Assessment
dc.subject.meshSeverity of Illness Index
dc.subject.meshTiotropium Bromide
dc.subject.meshTreatment Outcome
dc.titleCOPD clinical control as a predictor of future exacerbations: concept validation in the SPARK study population.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number75

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