COPD clinical control as a predictor of future exacerbations: concept validation in the SPARK study population.
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2020-02-10
Authors
Barrecheguren, Miriam
Kostikas, Konstantinos
Mezzi, Karen
Shen, Steven
Alcazar, Bernardino
Soler-Cataluña, Juan José
Miravitlles, Marc
Wedzicha, Jadwiga A
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Abstract
The concept of chronic obstructive pulmonary disease (COPD) control has been proposed to guide treatment decisions in COPD. In this study, we aimed to validate the prospective value of this concept in the SPARK study population. Control was assessed based on COPD stability and impact. Patients with low impact and stability during weeks 1-12 were classified as controlled, and exacerbations were measured during a 52-week follow-up. Of the 2044 patients included a majority were non-controlled (80%), frequently due to high impact. During the follow-up, the rate of moderate/severe exacerbations was significantly lower in controlled patients (rate ratio, 0.56, 95% CI 0.48 to 0.65 p
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MeSH Terms
Aged
Bronchodilator Agents
Disease Progression
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Drug Therapy, Combination
Female
Glycopyrrolate
Humans
Indans
Male
Middle Aged
Prospective Studies
Pulmonary Disease, Chronic Obstructive
Quinolones
Reproducibility of Results
Respiratory Function Tests
Risk Assessment
Severity of Illness Index
Tiotropium Bromide
Treatment Outcome
Bronchodilator Agents
Disease Progression
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Drug Therapy, Combination
Female
Glycopyrrolate
Humans
Indans
Male
Middle Aged
Prospective Studies
Pulmonary Disease, Chronic Obstructive
Quinolones
Reproducibility of Results
Respiratory Function Tests
Risk Assessment
Severity of Illness Index
Tiotropium Bromide
Treatment Outcome
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Keywords
COPD Exacerbations